Waldenstrom's Macroglobulinemia

In Waldenstrom's macroglobulinemia, abnormal plasma cells build up in the bone marrow, lymph nodes, and spleen. They make too much M protein, which causes the blood to become thick. The lymph nodes, liver, and spleen may become swollen. The thickened blood may cause problems with blood flow in small blood vessels.

Symptoms of macroglobulinemia depend on the part of the body affected. Most patients with macroglobulinemia have no symptoms. A doctor should be consulted if any of the following problems occur:

  • Feeling very tired.
  • Headache.
  • Nosebleeds.
  • Vision changes such as blurred vision or bulging eyes.
  • Dizziness.
  • Pain, tingling, or numbness in the hands, feet, fingers, toes, or other parts of the body.
  • Trouble walking.
  • Confusion.
  • Pain or a feeling of fullness below the ribs on the left side.
  • Painless lumps in the neck, underarm, stomach, or groin.