Smoldering Multiple Myeloma (SMM)

In this type of plasma cell neoplasm, plasma cells may make up ten percent or more of the bone marrow. The abnormal plasma cells produce M protein that may be found during a routine blood or urine test and is generally greater than 30 g/L. Smoldering MM signifies early disease and symptoms such as anemia, renal failure, hypercalcemia or bone lesions are not generally observed at this stage. Since disease is not yet active, SMM is usually observed to watch for disease progression, but not treated. There is newer data suggesting that some types of smoldering MM may benefit from therapy.  However, this depends on a number of different factors, and is important to talk about when you see a myeloma expert.