Traumatic Brain Injury Research
Neuropsychology Division faculty members serve as principal investigators, co-investigators, and consultants on a variety of studies in the area of traumatic brain injury. Research projects examine genetic, hormonal and health economic determinants of outcome following traumatic brain injury. Other studies examine response to psychostimulant medication or the use of anticholinesterase inhibitors to treat cognitive dysfunction. While a number of studies have been completed and are pending publication, many studies continue to actively recruit brain injury survivors. Dr. Anthony Stringer serves as principal investigator of the Georgia Model Brain Injury System (GAMBIS). Additional information on GAMBIS studies may be found at www.gambis.emory.edu.

An fMRI Study of Executive Functioning After Traumatic Brain Injury (open to enrollment)

Apolipoprotein E Genotype and Outcome Following Traumatic Brain Injury (closed to enrollment)

Does Gender Influence Outcome following Traumatic Brain Injury? (closed to enrollment)

Effects of Methylphenidate on Working Memory Inhibition Tasks and Functional Magnetic Resonance Imaging After Traumatic Brain Injury (open to enrollment)

Insurance Benefits as an Outcome Predictor in TBI Rehabilitation (closed to enrollment)

Determinants of Quality of Life Following Traumatic Brain Injury (closed to enrollment)

Neuropsychological Outcome and Community Re-integration Following Traumatic Brain Injury: The Impact of Frontal and Non-frontal Lesions (study completed)

Pharmacogenetics Evaluation of Response to Exelon in Patients with Traumatic Brain Injury with Persistent Cognitive Deficits (open to enrollment)

Severity of Injury and Service Utilization Following Traumatic Brain Injury (closed to enrollment)

Symptoms of Post-traumatic Stress at 6 and 12 Months After Traumatic Brain Injury (closed to enrollment)

A Twelve Week, Prospective, Double-blind, Placebo-controlled, Multicenter Study Evaluating the Efficacy and Safety of Exelon in Patients with Traumatic Brain Injury with Persisting Cognitive Deficits (open to enrollment)

Twenty-six Week Open Label Extension to A Twelve Week, Prospective, Double-blind, Placebo-controlled, Multicenter Study Evaluating the Efficacy and Safety of Exelon (open to enrollment)

Epilepsy Research

The Neuropsychology Division participates in several multicenter clinical trials of innovative treatments for intractable epilepsy. Studies examine the use of fetal porcine neuronal stem cell implants and early surgical intervention for temporal lobe epilepsy. The Neuropsychology Division has initiated pilot studies of neurofeedback in the treatment of temporal lobe epilepsy and a comparison of transcranial magnetic stimulation to the Wada Test in the assessment of memory function. Additional studies examine the neonatal consequences of maternal use of anticonvulsant medication.

Early Randomized Surgery for Epilepsy Trial (ERSET) (open to enrollment)

Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) (open to enrollment)

Neurofeedback for Limbic Temporal Lobe Epilepsy: A Pilot Study of a Complementary Treatment for a Neurodevelopmental Disorder (open to enrollment)

A Pilot Short Safety and Feasibility Study of Implanting GABA-producing Porcine Fetal Neuronal Cells into Epileptogenic Tissue of Patients with Focal Epilepsy (open to enrollment)

Retrospective Study of Anti-epileptic Drug Effects on Neurodevelopment (open to enrollment)

Transcranial Magnetic Stimulation in the Determination of Memory Capacity in an Epilepsy Population (open to enrollment)