This disease covers a number of abnormalities of the tricuspid valve, which separates the upper right and lower right chambers of the heart. Ebstein’s anomaly can result in severe tricuspid valve regurgitation (reverse blood flow), heart rhythm disorders and associated atrial septal defects. The severity of the disease can vary greatly: Some people with Ebstein’s anomaly require heart valve replacement, while others may only develop a mild heart rhythm disorder. Follow-up as an adult in extremely important in both repaired and unrepaired patients.