Research Projects

Below is a list highlighting the projects and accomplishments of our ESHM CRP investigators and other ESHM faculty:

Research Projects involving Hospital Medicine Clinical Research Program Investigators

Prognostic utility of biomarkers of collagen turnover, matrix metalloproteinases (MMP 2, 3, and 9) and tissue-inhibitors of metalloproteinases (TIMP-1, TIMP-2) over contemporary prediction models, and their correlation with cardiac function and exercise capacity in patients with low ejection fraction heart failure
Researcher: Vikas Bhalla MD
Hypothesis: Biomarkers of collagen turnover will correlate strongly with both cardiac structure & function and functional capacity in low ejection fraction heart failure patients.

Characteristics of peripherally inserted central catheters (PICCs): an analysis of patient characteristics, patterns of use, prevalence, necessity, complications, and alternatives in the hospital setting 
Researchers: Brian C. Erb MD FASN, David Tong MD MPH
Hypothesis: We hypothesize that the prevalence and duration of PICCs are unnecessarily high and that opportunities can be identified to reduce patient exposure to the hazards associated with PICCs, in particular for patients with chronic kidney disease.

Goal-directed teamwork to improve frontline patient care
Researchers: Julie Hollberg MD, Jason Stein MD
Hypothesis: Highly functional frontline teams can be created through particular staffing models, rounding formats, use of daily goals checklists, and attention to dimensions of teamwork, such as cohesiveness, communication, role clarity, and goal clarity.

Prevalence, risk factors, and impact on clinical outcome of multi-drug resistant organisms: Carbapenem-resistant Klebsiella pneumoniae
Researchers: Ketino Kobaidze MD PhD
Hypothesis: A better understanding of transmission of Carbapenem-resistant Klebsiella pneumoniae will improve the effectiveness of the infection control program across Emory hospitals.

Prevalence of abnormal values and effect of alerts at the time of discharge
Researcher: George Mathew MD
Hypothesis: Dynamically generated electronic alerts at time of discharge by CPOE (computerized physician order entry), triggered by specific abnormal vital sign or laboratory values, will help identify and alter management decisions for patients in a large tertiary care hospital.

DiaSys: Computerized decision support to improve diabetes management in primary care
Researcher: Arun Mohan MD MBA
Hypothesis: Decision support technology will provide primary care providers with individualized treatment recommendations, and the underlying rationale; decision support recommendations for changes in therapy witll be considered valid by endorinologists; use of glucose monitoring-based computerized decision support by PCPs and their nursing staff will be feasible, safe, and effective.

Improving glycemic control in hospitalized ICU and non-ICU patients
Researcher: Hasan Shabbir MD
Hypothesis: To capture the potential strengths of team-based care and specialist oversight, we hypothesize that a glycemic control order set combined with real-time nursing interventions can improve best-practice utilization for glycemic control among hospitalized patients.

Improving glycemic control in hospitalized patients through a novel insulin drip conversion equation to standardize transition to subcutaneous insulin 
Researcher: Randy Smith MD
Hypothesis: We hypothesize that for patients on insulin infusions, if an equation that takes into account caloric intake and intravenous insulin needs is used to determine subcutaneous insulin dosage, glycemic control will be achieved more predictably and rapidly than if a physician uses other means to determine subcutaneous insulin dosage.

Increasing prevalence of venous thromboembolism (VTE) prophylaxis in the hospital through measure-vention
Researcher: Jason Stein MD
Hypothesis: Real-time measurement to identify patients without VTE prophylaxis can serve as both an intervention and a measurement system to increase and track prevalence of VTE prophylaxis.

Reducing central line associated blood stream infections (CLABSIs) and eliminating the idle central venous catheter through measure-vention
Researcher: Sheri Chernetsky Tejedor MD
Hypothesis: Real-time measurement to identify patients with central lines can serve as both an intervention and a measurement system to prompt removal of idle central lines.

Improving transfusion utilization among inpatient physicians
Researcher: Dan VanderEnde MD DTM&H
Hypothesis: An educational program with audit-and-feedback can improve transfusion practices in the hospital.  

Prospective evaluation of hospitalist and intensivist staffing models in the intensive care unit
Researcher: Kristin Wise MD
Hypothesis: Hospitalists can provide equivalent mortality outcomes for critically ill patients.


Collaborative Research Projects Involving Hospital Medicine Investigators

Antibiotic stewardship to reduce C. difficile colitis
Researchers: James Stone MD, Hasan Shabbir MD

Blood product restriction on a community hospital
Researchers: Hasan Shabbir MD, Sasi Ponnambalam MD

Comparison of a novel silver-coated catheter access device and a standard catheter access (funded by Baxter Healthcare)
Researchers: Jay Steinberg MD, Sheri Tejedor MD, Jesse Jacobs MDHospital medicine off service notes improvement
Researchers: Hasan Shabbir MD, Sukit Chaiyachati MD

Designing a quality program for a Department of Medicine  
Researchers: Jason Stein MD, Marjan Khosravanipour MPH, Justin Rykowski

Improving inpatient glycemic control in cystic fibrosis related diabetes (funded by the Cystic Fibrosis Foundation)
Researcher: David Tong MD MPH, Lindy Wolfenden MD, Vin Tangpricha MD

Low risk chest pain and effectiveness of 23 hr observation
Researchers: Dapo Odetoyinbo MD MPH, Hasan Shabbir MD

Molecular epidemiology of Carbapenem-resistant Klebsiella pneumoniae among Emory affiliated hospitals
Researchers: Ketino Kobaidze MD PhD, Carolyn Gould MD, Eileen Burd PhD

Multi-center intervention to improve patient satisfaction
Researchers: Dapo Odetoyinbo MD MPH, Christin Ko MD, Shasi Poddar MD, Karen Clarke MD MS MPH, Jason Stein MD

Optimizing work-up of syncope 
Researchers: Alan Wang MD, Hasan Shabbir MD

Predicting capacity for teamwork and leadership in hospital medicine
Researchers: Bryce Gartland MD, Alan Wang MD, Dallas Howard-Crow, Jason Stein MD

Preventing hospital-acquired urinary tract infections 
Researchers: Karen Clarke MD MS MPH

Professional development for hospital medicine physicians in a hybrid community-academic program
Researchers: Christin Ko MD, Jason Stein MD, Barbara Rogers MBA, Alan Wang MD, Dan Dressler MD MSc

Reduction of adverse drug events reduction
Researchers: Hasan Shabbir MD

Standardized web-based hand-off tool to improve the quality of medicine resident sign-out 
Researchers: Christina Payne MD, Dan Dressler MD MSc, Jason Stein MD