Costas Hadjipanayis, MD, PhD

Hadjipanayis

Costas Hadjipanayis, MD, PhD
Chief of Neurosurgery Service, Emory University Hospital Midtown
Associate Professor, Department of Neurosurgery
Director, Brain Tumor Nanotechnology Laboratory
President, Southeastern Brain Tumor Foundation

The Emory Clinic, Building B, 2nd floor
1365-B Clifton Rd., NE, Ste. 2200
Atlanta, GA 30322

To make an appointment: 404-778-5770

Dr. Hadjipanayis received his medical degree from Jefferson Medical College of Thomas Jefferson University and completed his residency in neurosurgery at the University of Pittsburgh School of Medicine, simultaneously obtaining his PhD from the Department of Molecular Genetics and Biochemistry. He served on the medical staff of the University of Pittsburgh Medical Center before joining Emory's faculty, where he is now Chief of Neurosurgery Service at Emory University Hospital Midtown and a member of Winship Cancer Institute. He has been designated a Georgia Cancer Coalition Distinguished Scholar, and was elected 2011 President of the Southeastern Brain Tumor Foundation.

Dr. Hadjipanayis specializes in surgical neuro-oncology (surgery of the brain and spine) and the development of novel therapeutics for brain tumors. He performs delicate operations specializing in the removal of brain tumors (cancerous and non-cancerous), skull base tumors, spinal tumors and experimental treatments for malignant tumors. Dr. Hadjipanayis specializes in minimally-invasive neuro-endoscopic procedures to treat disorders in the brain, and endoscopic procedures for the removal of skull base tumors through the nose. He is the only neurosurgeon in Georgia performing neuroendoscopic resection of colloid cyst brain tumors.

Learn more about endoscopic resection of brain tumors.

Areas of Clinical Interest:

  • surgical neuro-oncology
  • stereotactic radiosurgery and brain biopsies
  • experimental therapeutics for malignant glioma
  • complex cervical, thoracic and lumbar spinal instrumentation
  • microvascular decompression
  • neuro-endoscopy
  • peripheral nerve
  • spinal tumor removal
  • spinal reconstruction

Publications

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Doctoral Dissertation

Hadjipanayis CG. Radiosensitivity enhancement of human glioblastoma multiforme by a herpes simplex virus vector. School of Medicine, Biochemistry and Molecular Genetics Graduate Program, University of Pittsburgh, 2005. 


Refereed Publications

Gower BA, Hadjipanayis C, Nagy TR, Stetson MH. Response of collared lemmings to melatonin: II. Infusions and photoperiod. Journal of Pineal Research 17:185-194, 1994.

Hadjipanayis CG and Plata-Salaman CR. My experience with 33 patients infected with HIV. Delaware Medical Journal 68(2):143-145, 1996.

Hadjipanayis CG, Levy EI, Niranjan A, Firlik AD, Kondziolka D, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for motor cortex region arteriovenous malformations. Neurosurgery 48(1):70-77, 2001.

Tyler-Kabara EC, Kassam AB, Horowitz MH, Urgo L, Hadjipanayis C, Levy EI, Chang YF. Management of typical and atypical trigeminal neuralgia: predictors of outcome for microvascular decompression. Journal of Neurosurgery 96(3):527-531, 2002.

Hadjipanayis CG, Gardner P, Dagam S, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD. Stereotactic radiosurgery when multimodality therapy is necessary for pilocytic astrocytomas. Journal of Neurosurgery, 97(1):56-64, 2002.

Hasegawa T, Kondziolka D, Hadjipanayis CG, Flickinger JC, Lunsford LD. The role of stereotactic radiosurgery for the treatment of parenchymal pineal tumors. Neurosurgery 51(4):880-889, 2002.

Hadjipanayis CG, Niranjan A, Tyler-Kabara EC, Kondziolka D, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for well circumscribed fibrillary grade II astrocytomas: an initial experience. Stereotactic and Functional Neurosurgery 79(1):13-24, 2002.

Hadjipanayis CG, Bejjani G, Wiley C, Hasegawa T, Maddock M, Kondziolka D. Intracranial Rosai Dorfman Disease Treated By Microsurgical Resection and Stereotactic Radiosurgery: Case Report. Journal of Neurosurgery, 98(1):165-168, 2003.

Hasegawa T, Kondziolka D, Hadjipanayis CG, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for CNS non-germinomatous germ cell tumors: report of four cases. Pediatric Neurosurgery 38(6), 2003.

Hasegawa T, Kondziolka D, Hadjipanayis CG, Lunsford LD. Management of cystic craniopharyngiomas with phosphorus-32 intracavitary irradiation. Neurosurgery 54(4), 2004.

Harris AH, Hadjipanayis CG, Lunsford AK, Lunsford LD, Kassam AB. CT-guided stereotactic microsurgical removal of intraventricular lesions assisted by endoscopy. Neurosurgery (Operative Neurosurgery Suppl.) 56, 2005.

Albright L, Hadjipanayis CG, Lunsford LD, Kondziolka DK, Pollack IF, Adelson PD. Individualized treatment of pediatric craniopharyngiomas. Childs Nervous Syst. 21(8-9):649-654, 2005.

Hadjipanayis CG and DeLuca N. Inhibition of DNA repair by a herpes simplex virus vector enhances the radiosensitivity of human glioblastoma cells. Cancer Research 64(12):5310-5316, 2005.

Berger MS and Hadjipanayis CG. Surgery of intrinsic cerebral tumors. Neurosurgery (30th Year Anniversary Suppl), 2007.

Hadjipanayis CG, Fellows-Mayle W, DeLuca N. In vivo efficacy of herpes simplex virus ICP0 in combination with radiation for the treatment of intracranial glioblastoma after convection- enhanced delivery. (Manuscript to be submitted to Cancer Research).

Harris AE, Hadjipanayis CG, Lunsford LD, Lunsford AK, Kassam AB. Microsurgical removal of intraventricular lesions using endoscopic visualization and stereotactic guidance. Neurosurgery (30th Year Anniversary Suppl Part 2), 62(2 Suppl):125-131, 2008.

Hadjipanayis CG, Bonder MJ, Balakrishnan S, Wang X, Mao H, Hadjipanayis GC. Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small 4(11):1925- 1929, 2008.

Hadjipanayis CG, Fellows-Mayle W, DeLuca N. Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery. Molecular Therapy 16(11):1783-1788, 2008

Hadjipanayis CG, Van Meir EG. Tumor initiating cells in malignant gliomas: biology and implications for therapy. J Mol Med. 2009 Apr;87(4):363-74. Epub 2009 Feb 3. Review. PubMed PMID: 19189072; PubMed Central PMCID: PMC2693383.

Hadjipanayis CG, Schuette AJ, Boulis N, Hao C, Barrow DL, Teo C. Full scope of options. Neurosurgery. 2010 Jul;67(1):197-203; discussion 203-4. PubMed PMID: 20559107; PubMed Central PMCID: PMC2888508.

Hadjipanayis CG, Machaidze R, Kaluzova M, Wang L, Schuette AJ, Chen H, Wu X, Mao H. EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res. 2010 Aug 1;70(15):6303-12. Epub 2010 Jul 20. PubMed PMID: 20647323; PubMed Central PMCID: PMC2912981.

Tzitzios V, Basina G, Bakandritsos A, Hadjipanayis CG, Mao H, Niarchos D, Hadjipanayis GC, Tucek J, Zboril R. Immobilization of magnetic iron oxide nanoparticles on laponite discs - an easy way to biocompatible ferrofluids and ferrogels. J Mater Chem. 2010 Jan 1;20(26):5418-5428. PubMed PMID: 20582149; PubMed Central PMCID: PMC2889675.

Schuette AJ, Taub JS, Hadjipanayis CG, Olson JJ. Open biopsy in patients with acute progressive neurologic decline and absence of mass lesion. Neurology. 2010 Aug 3;75(5):419-24. PubMed PMID: 20679635; PubMed Central PMCID: PMC2918468.

Invited Publications

Hadjipanayis CG and Lunsford LD. Low-grade fibrillary astrocytomas. Contemporary Neurosurgery 23(21):1-6, 2001.

Hadjipanayis CG, Kondziolka D, Flickinger JC, Lunsford LD. The role of stereotactic radiosurgery for low-grade astrocytomas. Neurosurgical Focus 14(5), 2003.

Hadjipanayis CG, Abla A, El-Kadi M, Maroon JM. Pedicle fixation of the lumbar spine involving the sacrum. Contemporary Neurosurgery 25(7), 2003.

Berger MS and Hadjipanayis CG. Surgery of intrinsic cerebral tumors. Neurosurgery (30th Year Anniversary Suppl), 2007.

Harris AE, Hadjipanayis CG, Lunsford LD, Lunsford AK, Kassam AB. Microsurgical removal of intraventricular lesions using endoscopic visualization and stereotactic guidance. Neurosurgery (30th Year Anniversary Suppl Part 2), 62(2 Suppl):125-131, 2008.

Hadjipanayis CG and Van Meir EG. Tumor initiating cells in malignant gliomas: biology and implications for therapy. J Mol Med. 2009 Apr;87(4):363-74. Epub 2009 Feb 3. Review.

Hadjipanayis CG, Van Meir EG. Brain cancer propagating cells: biology, genetics and targeted therapies. Trends Mol Med. 2009 Nov;15(11):519-30. Epub 2009 Nov 2. Review. PubMed PMID: 19889578; PubMed Central PMCID: PMC2782740.

Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY, Olson JJ. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin. 2010 May-Jun;60(3):166-93. Review. PMID: 20445000

Book Chapters

Bejjani G, Hadjipanayis CG, Couce M: Oligodendroglioma. In: Atlas of Neurosurgical Techniques. Fessler RG and Sekhar LN (Eds.). Thieme Medical Publishing, New York, 2006.

Grandi P, Bein K, Hadjipanayis CG, Breakefield XO, Glorioso J: Application of HSV-1 vectors in the treatment of cancer. In: Viral Therapy of Cancer. Harrington K, Panda H, Vile R (Eds.). Wiley Publishing, 2007.

Hadjipanayis CG: Herpes simplex virus 1 (HSV-1) for malignant glioma therapy. In: CNS Cancer (Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches). Van Meir EG (Editor). Humana Press, Springer Publishing, 2009.

Dadashev V, Laborde D, and Hadjipanayis CG: Endoscopic endonasal skull base surgery. In: Skull Base Techniques and Concepts. Moore CE and Olson JJ (Editors). Plural Publishing, 2010.

Published Abstracts

Komarnicky LT, Anne PR, Corn B, Hadjipanayis C, Mansfield CM, Swensson L. Bilateral breast cancer: an evaluation of risk factors and outcome. International Journal of Radiation Oncology, Biology, and Physics 36 (Suppl. 1):38, 1996.

Komarnicky LT, Anne PR, Corn B, Hadjipanayis C, Mansfield CM, Swensson L. Bilateral breast cancer: an evaluation of risk factors and outcome. The Breast Journal 5 (1):36, 1999.

Hadjipanayis CG, Levy EI, Niranjan A, Firlik AD, Kondziolka D, Flickinger JC, Lunsford LD. Stereotactic radiosurgery in the management of motor cortex region arteriovenous malformations. Neurosurgery 45(3):696, 1999.

Hadjipanayis CG, Hasegawa T, Kondziolka D, Lunsford LD. Phosphorus-32 intracavitary irradiation for patients with cystic craniopharyngiomas. Journal of Neurosurgery 98:A660, 2003.

Hadjipanayis CG, Deluca NA. Radiosensitivity enhancement of glioblastoma multiforme by an HSV vector. Proc Amer Assoc Cancer Res 45, 2004

Hadjipanayis CG, Deluca NA. Degradation of the catalytic subunit of DNA-dependent protein kinase by a herpes simplex virus vector enhances the radiosensitivity of human glioblastoma cells. Neuro-oncology 6(4):360, 2004

Hadjipanayis CG, Fellows-Mayle W, DeLuca NA. DNA repair inhibition enhances the chemoradiosensitivity of experimental glioblastoma multiforme after convection-enhanced delivery. Journal of Neurosurgery 104(4):A661, 2006.

Hadjipanayis CG, Fellows-Mayle W, Deluca N. In vivo efficacy of herpes simplex virus ICP0 in the combination with radiation for the treatment of intracranial glioblastoma after convection- enhanced delivery. Neuro-oncology 9(4):484, 2007.

Hadjipanayis CG, Machaidze R, Van Meir E, Deluca N. Novel replication-competent herpes simplex virus and therapy of experimental glioblastoma multiforme. Neuro-oncology 10(5):794, 2008. 10. Olson J, Zhang Z, Hadjipanayis CG, New P. Preclinical analysis of Depocyt therapy for intracerebral tumors. Neuro-oncology 10(5):789, 2008.

Educational Courses Directed

Depuy Neurosurgery Resident Cadaver Spine Dissection, Emory University School of Medicine, November 7, 2008. Course Director: Costas G. Hadjipanayis, M.D., Ph.D.

International Intraventricular and Skull Base Neuro-endoscopy-A Hands-On Course (CME Accreditation), Emory University School of Medicine, June 3-5, 2009. Course Director: Costas G. Hadjipanayis, M.D., Ph.D.

Spinal Tumor Radiosurgery: A Multidisciplinary Approach at Emory University Hospital Midtown (CME Accreditation), Emory University Hospital Midtown, March 12, 2010. Course Co-Director: Costas G. Hadjipanayis, M.D., Ph.D.