Nelson M. Oyesiku, MD, PhD, FACS

Nelson Oyesiku 

Nelson M. Oyesiku, MD, PhD, FACS
Al Lerner Chair and Professor, Departments of Neurosurgery and Medicine (Endocrinology)
Director, Molecular Neurosurgery and Biotechnology Laboratory
Program Director, Neurosurgery Residency Program
Editor-In-Chief, Neurosurgery

The Emory Clinic, Building B, 2nd floor
1365-B Clifton Rd., NE, Ste. 2200
Atlanta, GA 30322

To make an appointment: 404-778-5770

Dr. Oyesiku was born in Nigeria where he graduated from St. Gregory’s College and received his medical degree from the University of Ibadan. He then attended the University of London, UK as a Commonwealth Scholar where he obtained a Masters of Science degree. He obtained his neurosurgical training at Emory University. During his residency he also completed a PhD degree in neuroscience at Emory University, studying the role of neurotrophic factors in neuronal survival and regeneration.

Dr. Oyesiku was appointed to the neurosurgical faculty at Emory upon completion of his training. He is currently Professor of Neurological Surgery and Professor of Medicine (Endocrinology) at Emory University. He occupies the Al Lerner Chair in Neurosurgery and is Vice-Chairman of the department and Director of the Neurosurgical Residency Program.

Dr. Oyesiku’s clinical and research focus is the surgical treatment and molecular biology of pituitary tumors. He partners with Adriana Ioachimescu, MD, PhD and a team of endocrinologists who collaborate in the diagnosis, treatment and care of patients with pituitary tumors at Emory's Pituitary Neuroendocrine Center. Dr. Oyesiku is also Director of the Laboratory of Molecular Neurosurgery and Biotechnology, which has identified unique aspects of pituitary adenoma gene expression and has developed a new modality for imaging and targeted therapy of pituitary tumors. Dr. Oyesiku received an NIH CIDA Award and Medical Faculty Development Award from the Robert Wood Johnson Foundation, is a recipient of an NIH RO1 award for the molecular imaging and targeting of pituitary tumors, and is PI of the R25 NIH training grant for Neurosurgery.

In 2009, Dr. Oyesiku was named Editor-in-Chief of Neurosurgery, the official journal of the Congress of Neurological Surgeons (CNS). He is also an ad hoc reviewer for several peer-reviewed journals. Dr. Oyesiku has served Emory University, the Emory Clinic and Emory Hospital on various committees, and has also served on several state and regional committees. He has been selected by his peers as one of The Best Doctors in America, was selected by the Consumer Research Council of America as one of America’s Top Surgeons, and is named in Marquis Who’s Who in America. Dr. Oyesiku has been visiting professor at several departments of neurosurgery throughout the United States and abroad. He has authored several manuscripts, book chapters and a book in the field of neurosurgery.

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Areas of Clinical Interest:

  • pituitary tumors
  • stereotactic radiosurgery

Society Memberships:

  • American College of Surgeons: Fellow; Board of Governors; Advisory Council for Neurosurgery
  • Congress of Neurological Surgeons: Past President; Past Chair, CNS International Committee; Executive Committee; Publications Committee; Co-Chair, Scientific Program Committee (2002); Scientific Program Chairman (2003); Annual Meeting Chairman (2004)
  • CNS Joint Section of Neurotrauma/Critical Care: Executive Committee
  • CNS Joint Section of Tumors: Executive Committee
  • Federation for International Education in Neurosurgery: Board of Directors
  • Georgia Neurosurgical Society: Past President, Secretary and Treasurer
  • Society of Neurological Surgeons: Chairman, Match Committee
  • World Federation of Neurosurgical Societies: CNS Delegate; Chair, Neuroendocrine Committee

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Publications (post-2000)

Evans, C-O, Oyesiku N.M., Brown, M.S , Parks, J.S. Screening for MEN-I Tumor Suppressor Gene Mutations in Sporadic Pituitary Tumors. J Endocrinological Investigation 23:304-309, 2000.

Schultz A., Brat DJ, Oyesiku N.M., Hunter S., Intrasellar Pituitcytoma in a patient with other endocrine neoplasms Archives of Pathology and Laboratory Medicine 125: 527-530, 2001.

Evans C-O, Young A N, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku N.M. Novel patterns of gene expression in pituitary adenomas identified by cDNA microarrays and quantitative RT-PCR. Journal of Clinical Endocrinology and Metabolism, 86: 3097-3107, 2001.

Biousse V., Newman, N.J., Oyesiku, N.M. Precipitating factors in pituitary apoplexy. J Neurol Neurosurg Psychiatry, 71:542-545, 2001.

Alleyne C.H. Jr., Barrow, D.L., Oyesiku N.M. Combined transsphenoidal and pterional craniotomy approach to giant pituitary tumors. Surgical Neurology 57:380-390, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Guidelines for Management of Acute Cervical Spinal Injuries, Neurosurgery 50:S1-6, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Cervical Spine Immobilization before Admission to the Hospital, Neurosurgery 50:S7-17, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Transportation of Patients with Acute Traumatic Cervical Spine Injuries, Neurosurgery 50:S18-20, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Clinical Assessment after Acute Cervical Spinal Cord Injury, Neurosurgery 50:S21-29, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Radiographic Assessment of the Cervical Spine in Asymptomatic Trauma Patients, Neurosurgery 50:S30-35, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Radiographic Assessment of the Cervical Spine in Symptomatic Trauma Patients, Neurosurgery 50:S36-43, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Initial Closed Reduction of Cervical Spine Fracture-Dislocation Injuries, Neurosurgery 50:S44-50, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Acute Spinal Cord Injuries in an Intensive Care Unit or Other Monitored Setting, Neurosurgery 50:S51-57, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Blood Pressure Management after Acute Spinal Cord Injury, Neurosurgery 50:S58-62, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Pharmacological Therapy after Acute Cervical Spinal Cord Injury, Neurosurgery 50:S63-72, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Deep Venous Thrombosis and Thromboembolism in Patients with Cervical Spinal Cord Injuries, Neurosurgery 50:S73-80, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Nutritional Support after Spinal Cord Injury, Neurosurgery 50:S81-84, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Pediatric Cervical Spine and Spinal Cord Injuries, Neurosurgery 50:S85-99, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Spinal Cord Injury without Radiographic Abnormality, Neurosurgery 50:S100-104, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Diagnosis and Management of Traumatic Atlanto-occipital Dislocation Injuries, Neurosurgery 50:S105-113, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Occipital Condyle Fractures, Neurosurgery 50:S114-119, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Isolated Fractures of the Atlas in Adults, Neurosurgery 50:S120-124, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Isolated Fractures of the Axis in Adults, Neurosurgery 50:S125-139, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Combination Fractures of the Atlas and Axis in Adults, Neurosurgery 50:S140-147, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Os Odontoideum, Neurosurgery 50:S148-155, 2002. Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Treatment of Subaxial Cervical Spinal Injuries, Neurosurgery 50:S156-165, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Acute Central Cervical Spinal Cord Injuries, Neurosurgery 50:S166-172, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Vertebral Artery Injuries after Nonpenetrating Cervical Trauma, Neurosurgery 50:S173-178, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku N.M., Przybylski G.J., Resnick D.K., Ryken T.C., Mielke DH. Guidelines for the management of acute cervical spine and spinal cord injuries. Clinical Neurosurgery. 49:407-98, 2002.

Evans, C-O, Reddy, P, Brat D.J., O'Neill E.B., Branch B., Stevens, V.L., Oyesiku, N.M., Differential Expression of Folate Receptor in Pituitary Adenomas, Cancer Research 63:4218-4224, 2003.

Zhan, X, Evans, C-O, Oyesiku, N.M., Desiderio D Proteomics and transcriptomics analyses of secretagogin down regulation in human non-functional pituitary adenomas. Pituitary 6: 189-202, 2004.

Jun He; Evans, C-O, Stuart W. Hoffman; Oyesiku, N.M, Donald Stein Progesterone and Allopregnanolone Reduce Inflammatory Cytokines after Traumatic Brain Injury. Experimental Neurology, 189:404-412, 2004.

Oyesiku, N.M., Halkar R. K., Galt J. R., Faraj B. A., Evans C.O. SPECT/CT of FolateScan ( Tc-99m EC20) in pituitary tumors: A novel imaging tracer and Technique. Journal of Nuclear Medicine Vol 45 (5 S) 368P 2004.

Evans C-O, Young A N, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku N.M. Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. Oncomine Cancer Microarray Database (www.oncomine.org).

Todd J. Scarbrough T.J, Crocker I.R., Davis L.W., Barrow D.L., Fowler B.Z., Oyesiku N.M. Intracranial Arteriovenous Malformations Treated Utilizing a Linear Accelerator-Based Patient Rotator or Commercially Available Radiosurgery System. Stereotactic and Functional Neurosurgery 83:91-100, 2005.

Moreno C, Evans C-O, Okor M; Desiderio, D.M., Oyesiku N.M. Novel Molecular Signaling in Human Clinically Non-Functional Pituitary Adenomas by Gene Expression Profiling. Proceedings of the 13th World Congress of Neurological Surgery, Marrakech, Morocco, Medimond International Proceedings, pg 1151-1156, 2005, Medimond S.r.l., Bologna, Italy

Evans C-O, Halkar, R.K., Galt, J.R., Faraj, B.J. Oyesiku, N.M. Molecular Targeting and Imaging of Non- Functional Pituitary Tumors: Preliminary Results. Jpn J Neurosurg 15:437-443, 2006

Oyesiku NM. 2005 Congress of Neurological Surgeons Presidential Address. Homogeneity and heterogeneity: lessons from nature and society. Clinical Neurosurgery. 53:1-9, 2006.

Oyesiku N.M. Stereotactic Radiosurgery for Cushing’s Disease: a review. Neurosurgical Focus 23: 2007.

Evans, C-O, Moreno, C. Desiderio, Zhan, X., McCabe M.T., Vertino, P.M., Desiderio, D.M., Oyesiku N.M Molecular Pathogenesis of Human Prolactinomas Identified by Gene Expression Profiling, RT-qPCR, and Proteomic Analyses. Pituitary. 11:231-245, 2008.

Fisher, R. E., Siegel, B. A., Edell, S. L., Oyesiku N.M., Morgenstern, D.E., Messmann, R. A., Amato, R. J. Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor–Positive Solid Tumors. J Nucl Med 2008 49: 899-906., 2008.

VS Chhabra, Li A, Evans C, Oyesiku, N.M. Silent ACTH Adenomas: Clinical Experience and Biological Correlates Neurol Croat 57:Suppl 3 pp 28, 2008.

Evans C-O., Yao C., Laborde D., Oyesiku NM. Folate receptor expression in pituitary adenomas cellular and molecular analysis. Vitamins & Hormones. 79:235-66, 2008.

Srivatsa S, Ioachimescu AG, Oyesiku NM, Hunter SB. Visual vignette. Endocr Pract. 2008 Dec;14(9):1192. PubMed PMID: 19158060.

Yao C, Evans CO, Stevens VL, Owens TR, Oyesiku NM. Folate receptor alpha regulates cell proliferation in mouse gonadotroph alphaT3-1 cells. Exp Cell Res. 2009 Nov 1;315(18):3125-32. Epub 2009 May 14. PubMed PMID: 19446551.

Dhabaan A, Elder E, Schreibmann E, Crocker I, Curran WJ, Oyesiku NM, Shu HK, Fox T. Dosimetric performance of the new high-definition multileaf collimator for intracranial stereotactic radiosurgery. J Appl Clin Med Phys. 2010 Jun 21;11(3):3040. PubMed PMID: 20717077.

Oyesiku NM. The registrar. Neurosurgery. 2010 Nov;67(5):1165-6. PubMed PMID: 20948397.

Galt JR, Halkar RK, Evans CO, Osman NA, LaBorde D, Fox TH, Faraj BA, Kumar K, Wang H, Oyesiku NM. In vivo assay of folate receptors in nonfunctional pituitary adenomas with 99mTc-folate SPECT/CT. J Nucl Med. 2010 Nov;51(11):1716-23. Epub 2010 Oct 18. PubMed PMID: 20956474.

Shah R, Licata A, Oyesiku NM, Ioachimescu AG. Acromegaly as a cause of 1,25-dihydroxyvitamin D-dependent hypercalcemia: case reports and review of the literature. Pituitary. 2010 Dec 28. [Epub ahead of print] PubMed PMID: 21188640.

Muh CR, Boulis NM, Chandler WF, Barkan AL, Mosunjac MB, Oyesiku NM. Clinical problem solving: monster on the hook--case problems in neurosurgery. Neurosurgery. 2011 Mar;68(3):E874-82. Review. PubMed PMID: 21311284.

Oyesiku NM. Measuring excellence in neurosurgical competence and certification. Clin Neurosurg. 2010;57:91-3. PubMed PMID: 21280499.


Review Articles

Oyesiku N.M., Tindall G.T.: Neurosurgery - The year in Review -1988. Contemporary Neurosurgery Vol. 10., No. 27, 1989.

Oyesiku N.M., Colohan A.R.T. Moderate Head Injury: An Overview In NIH CNS Trauma Status Report, p 259-264, 1992.

Oyesiku, N.M. Management of Growth Hormone Secreting Adenomas: An Update, Thieme, 2002

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Book Chapters

Oyesiku N.M., Bakay R.A.E.: CNS Transplantation. In Neurosurgery - The Scientific Basis of Clinical Practice. Ed. 2., Crockard H.A., Hayward R.D, Hoff J.T. (eds) Blackwell Scientific Publications, Oxford. 1992 pp 448-469.

Oyesiku N.M., Barrow DL: Infectious, Traumatic and other Unusual Aneurysms. In: Current Treatment of Aneurysms. AANS Publications. William's and Wilkin's, Baltimore, pp 243-275,1993.

Oyesiku N.M., Bakay R.A.E., Surgery for Spinal Tumors. In Medical Care of the Surgical Patient, J.P. Lippincott, Philadelphia 1995 pp 602-604.

Oyesiku N.M.,., Tindall G.T.,: Pituitary Gland: Surgery A Problem Solving Approach, (ed. 2), John H. Davis, George F. Sheldon, C.V. Mosby, St Louis, 1995 pp 2363-2396.

Oyesiku N.M., Tindall G.T.: Management of Hypersecreting Pituitary Tumors. In The Practice of Neurosurgery Tindall G.T., Cooper P.R., Barrow D.L. (eds) William's and Wilkin's, Baltimore, 1996 pp 11351152.

Oyesiku N.M., Tindall G.T., Pituitary Tumors: Principles and Practice of Neurosurgical Critical Care. William's and Wilkin's, 1996.

Oyesiku N.M., Tindall G.T.: Endocrine-Inactive adenomas: surgical results and prognosis. In Pituitary Adenomas Landolt A.M., Vance, M.L., Reilly, P.L. (eds) Churchill-Livingstone, New York,1996 pp 377-383.

Barrow D.L., Oyesiku N.M., Distal Anterior Cerebral Aneurysms. In Neurosurgery Wilkin's and Rengachary (eds), William's and Wilkin's, pp 2327-2331, 1996.

Oyesiku N.M.,. Pituitary Tumors and Sheehan's Syndrome in Pregnant Women. In: Neurosurgical Aspects of Pregnancy. AANS Publications pp 77-84, 1996.

Oyesiku N.M.,., Alleyne C, G.T Tindall. Combined pterional and transsphenoidal approach to pituitary tumors. 1998 (in Pituitary Disorders: Comprehensive management Krisht AF & Tindall GT) Lippincott Williams & Wilkins, Baltimore, 1999 pp 369-373.

Oyesiku N.M., Alleyne C., Schwartzman S. Fungal infections of the Brain pp 123-139. In: Infections in Neurological Surgery. Osenbach R., Zeidman S. (Eds). Lippincott-Raven. 1999.

Olson JJ, Barrow, DL, Gilbert, MR, Oyesiku N.M., Intracranial Tumors in. Oxford Textbook of Surgery, 2000 Chap 44.3, 2801-2828.

Resnick, D.K., Oyesiku N.M.,. Assessment and Classification of Spinal Cord Injuries. In Neurotrauma: Evidence Based Answers to Common Questions Valadka A, and Andrews B. (Eds.)2002.

Oyesiku N.M., What is the best way to assess and classify head-Injured patients? In Neurotrauma: Evidence Based Answers to Common Questions Valadka A, and Andrews B. (Eds.) 2002.

Oyesiku N.M., Pathophysiology and Management of Endocrine Function, In Textbook of Neurological Surgery: Principles and Practice. Lippincott Williams & Wilkins, Philadelphia Batjer, HH & Loftus, CM (Eds), pp 713-725.

Oyesiku N.M., Clinically Nonfunctional Adenomas. In: Principles of Neurosurgery (2nd Ed) Ellenbogen, R & Rengachary, S (Eds) Elsevier 2002.

Oyesiku N.M., Assessment of Pituitary Function. In: Principles of Neurosurgery (2nd Ed) Ellenbogen and Rengachary, Elsevier 2002.

Oyesiku N.M. Transsphenoidal Surgery. In Medical Care of the Surgical Patient, (3rd Ed) Lubin, Walker, & Smith -Eds., J.P. Lippincott, Philadelphia, 2003

Evans C-O, Moreno C., Oyesiku N.M. Novel Molecular Signaling and Classification in Human Clinically Non-Functional Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction. In Contemporary Endocrinology: Genomics in Endocrinology: DNA Microarray Analysis in Endocrine Health and Disease. Edited by S.Handwerger and B. Aronow, Humana Press, Totowa, NJ, 2007

Muh, C.R., Oyesiku N.M. Non-functioning Adenomas: Diagnosis and Treatment . In Diagnosis and Management of Pituitary Disorders, Brooke Swearingen and Beverly M. K. Biller (eds.) Humana Press, Totowa, NJ, pp 271-288, 2008


Books

Oyesiku N.M., Amacher A.L. Patient Care in Neurosurgery 3rd Edition. Boston/Toronto. Little, Brown & Company, 1990.

Oyesiku N.M., Amacher A.L. Patient Care in Neurosurgery (Japanese Language Edition). Medical Sciences International Ltd. Tokyo, 1992.

Barrow DL, Tindall SC, Oyesiku N.M., Washington J, Hunter SB, Owens DS, Harper FN (eds). Neurosurgery Board Review, Questions and Answers for Self-Assessment, Alleyne CH Jr. New York/Stuttgart, Thieme 1997.

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Media Credits / Press Releases

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