Nicholas M. Boulis, MD
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Nicholas M. Boulis, MD The Emory Clinic, Building B, 2nd floor 1365-B Clifton Rd., NE, Ste. 2200 To make an appointment: 404-778-5770 |
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Dr. Nicholas Boulis is a physician scientist whose research interests include biological neurorestoration and neuromodulation through the use of cell, protein and gene delivery to the nervous system. Dr. Boulis graduated Summa Cum Laude from Yale University with distinction in intensive Biology and Philosophy majors and graduated Magna Cum Laude from Harvard Medical School, winning the Harold Lamport Biomedical Research Award.
Dr. Boulis developed a clinical program focusing on peripheral nerve regeneration, spasticity, pain and Parkinson's Disease, applying advanced microsurgical, radiosurgical and ablative and neural augmentation approaches. He has independently organized and secured funding for an outreach/teaching mission to provide surgical therapy to patients in Guatemala requiring treatment for hydrocephalus and spina bifida. To date, "Project Shunt" has provided over 250 free operations to impoverished Guatemalan children.
Areas of Clinical Interest:
- Functional Neurosurgery
- Trigeminal Neuralgia
- Refractory Pain
- Peripheral Nerve Surgery
(Below publications are a select list from post-2000)
Publications
Boulis NM. Sisyphus and the outpatients. (2000) Lancet 356: 350
Gong C, Boulis NM, Jun G, Turner DE, Hoff JT, Keep RF. (2001) Intracerebral Hemorrhage-induced neuronal death. Neurosurgery 48(4):875-82
Boulis NM, Mian F, Rodriguez DJ, Cho EJ, Hoff JT. (2001) Urinary retention in postoperative neurosurgical routine spine procedures. Surgical Neurology 55(1):23-7
Boulis NM, Noordmans AJ, Barkan A, Hassing J, Chandler WF (2000). Somatotropinoma infarction during Octreotide therapy leading to bilateral cavernous sinus syndrome. Pituitary 3:185-188
Turner DE, Noordmans AJ, Feldman EL, Boulis NM (2001). Remote adenoviral gene delivery to the spinal cord: contralateral delivery and reinjection. Neurosurgery 48(6):1309-1317
Boulis NM, Turner DE, Imperiale MJ, Feldman EL. (2002) Neuronal survival following remote adenoviral gene delivery. J Neurosurg:( Spine 2) 96: 212-219.
Song D, Boulis NM, McKeever, Quint D. (2002) Angiotropic large cell lymphoma presenting with imaging characteristics of CNS vasculitis. American Journal of Neuroradiology 23(2):239-42.
Rubin AD, Hogikyan ND, Sullivan K, Boulis N, Feldman EL. (2001) Remote delivery of rAAV-GFP to the rat brainstem through the recurrent laryngeal nerve. The Laryngoscope 111(11 Pt 1):2041-5.
Boulis NM. (2001) There was a young surgeon who swallowed a flea. Canadian Medical Association Journal165(12): 1613-1614.
Boulis NM, Willmarth NE, Song DK, Feldman EL, Imperiale MJ. (2003) Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery. Neurosurgery 52(2)381-387.
Rubin A, Hogikyan N, Bell K, Sullivan K, Boulis NM, Feldman EL. (2003) Remote delivery of an adenoviral vector to the crushed recurrent laryngeal nerve. Laryngoscope113: 985-989.
Noordmans AJ, Parent N, Bhatia V, Garrity-Moses M, Boulis NM. (2003) Rigid postoperative fixation for pedicled cranial flaps: A case comparison. J of Orthotics and Prosthetics15(1):27-30.
Boulis NM, Noordmans AJ, Song DK, Rubin A, Leone P, During M, Feldman EL, Imperiale MJ. (2003) Adeno-associated Viral Vector Gene Expression in the Adult Rat Spinal Cord Following Remote Vector Delivery. Neurobiology of Disease 14(3): 531-541.
Noordmans AJ, Song DK, Noordmans CJ, During MJ, Fitzsimons H, Imperiale MJ, Boulis NM. (2004) Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior. Gene Therapy 11: 797-804.
Tanase D, Teng Q, Krishnaney AA, Liu JK, Garrity-Moses ME, Mazarakis N, Boulis NM. (2004) Cervical spinal cord delivery of a rabies G protein pseudotyped lentiviral vector in the SOD-1 transgenic mouse. J Neurosug (Spine 1) 1: 128-136.
Teng Q, Tanase D, Liu J, Garrity-Moses M, Boulis NM. (2005) Adenoviral Tetanus Toxin Light Chain Gene-Based Synaptic Inhibition through Neuronal Synaptobrevin Elimination. Gene Therapy 12(2) 108-119.
Vincent A, Feldman E, Song D, Jung V, Schild A, Zhang W, Imperiale M, Boulis NM. (2004) Adeno-associated Viral-mediated Insulin-like Growth Factor Delivery Protects Motor Neurons In Vitro. NeuroMolecular Medicine 6(2/3): 79-85.
Schuele SU, Kellinghaus C, Shook S, Boulis NM, Bethoux FA, Loddenkemper T. (2005) Incidence of seizures in multiple sclerosis patients on intrathecal baclofen. Neurology, 64: 1086-1087.
Liu J,Teng Q, Garrity-Moses M, Tanase D, Imperiale M, Boulis NM. (2005) A Novel Peptide Defined Through Phage Display for Therapeutic Protein and Vector Neuronal Targeting. Neurobiology of Disease 19(3): 407-418.
Garrity-Moses M, Teng Q, Liu J, Tanase D, Boulis NM. (2005) Neuroprotective adeno-associated virus Bcl-xL gene transfer in models of motor neuron disease. Muscle and Nerve 32(6): 734-744.
Teng, Q, Garrity-Moses M, Tanase D, Liu JK, Mazarakis N, Azzouz M, Walmsley L, Carlton E, Boulis NM. (2005) Trophic activity of rabies G protein pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro. Neurobiology of Disease 20(3): 694-700.
Pilitsis JG, Rezai AR, Boulis NM, Hendersen JM, Busch RM, Kubu CS. (2005) A preliminary study of transient confusional states following bilateral subthalamic stimulation for Parkinson's disease. Stereotactic and Functional Neurosurgery 83(2-3): 67-70.
Salazar F, Machado A, Stevens G, Murthy S, Boulis NM. (2005) Thoracoscopically Guided Transaxillary Resection of Adjoining Intercostal Plexiform Neurofibromas; Review of Mosaicism in Neurofibromatosis. Neurosurgery 57(4)(Operative Neurosurgery Supp 4): E407.
Federici, T and Boulis, NM. (2006) Gene-based treatment of motor neuron disease. Muscle and Nerve 33(3): 302-323.
Zhao Z, Krishnaney A, Teng Q, Garrity-Moses M, Liu JK, Venkiteswaran K, Subramanian T, Davis M, Boulis NM. (2006) Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the deep layers of the superior colliculus/deep mesencephalic nucleus of the midbrain. Gene Therapy, 13; 942-952.
Garrity-Moses M, Teng Q, Krudy C, Yang J, Federici T, Boulis NM. (2006) XIAP Gene-based Neuroprotection for the Peripheral Nervous System. Neurosurgery 59(1): 172-182.
Federici T, Teng Q, Yang J, Garrity-Moses M, Boulis NM. (2006) Neuronal affinity of a C7C loop peptide identified through phage display. Journal of Drug Targeting, 14(5):263-71.
Federici T and Boulis NM. (2006) RNA interference for neurological disorders: candidate diseases, potential targets, and current approaches. Neurosurgery 60(1): 3-16.
Yang J, Teng Q, Garrity-Moses M, Federici T, Najm I, Chabardes S, Moffitt M, Boulis NM. (2007) Gene therapy of epilepsy by adenovirus-mediated tetanus toxin light chain gene transfer. Mol Therapy 15(3): 542-551.
McClelland S III, Teng Q, Benson LS, Boulis NM. (2007) Motor neuron inhibition-based gene therapy for spasticity. American Journal of Physical Medicine and Rehabilitation, 86(5): 412-421.
Federici T, Liu JK, Teng Q, Yang J, Boulis NM. (2007) Tet1, a means for targeting therapeutics to peripheral nervous system neurons with axon damage. Neurosurgery 60(5): 911-918.
Steinmetz MP, Krishnaney A, Boulis NM, Benzel EC. (2007) Clinical Problem Solving; An invasion of the Atlas. Neurosurgery 60(6): 1083-7.
Ford PJ, Boulis NM, Montgomery EB, Rezai AR. (2007) A patient revoking consent during awake craniotomy; An ethical challenge. Neuromodulation 10(4): 259-262.
Federici T and Boulis NM. (2007) Gene therapy for peripheral nervous system diseases. Current Gene Therapy, 7: 239-248.
Lotto M and Boulis NM. (2007) Intrathecal opioids for control of chronic low back pain during deep brain stimulation procedures. Anesthesia and Analgesia 105: 1410-1412.
Deogaonkar M, Walter B, Boulis NM, Starr P. (2007) Clinical Problem Solving; Find the target. Neurosurgery 61(4): 815-825.
Yang J, Qingshan T, Garrity-Moses ME, Federici T, McClelland S III, Boulis NM. (2007) Hemiparkinsonism induced through unilateral expression of adenovirus-mediated clostridial light chain gene in the substantia nigra. Neuromolecular Medicine, 9(3): 276-84.
Riley J, Butler J, Baker KB, McClelland S III, Teng Q, Yang J, Garrity-Moses M, Federici T, Boulis NM. (2008) Targeted spinal cord therapeutics delivery: stabilized platform and MER guidance validation. Stereotactic and Functional Neurosurgery 86: 67-74.
McClelland S III, Bethoux FA, Boulis NM, Sutliff MH, Stough DK, Schwetz KM, Gogol DM, Harrison M, Pioro EP. (2008) Intrathecal baclofen for spasticity-related pain in ALS: Efficacy and factors associated with pain relief. Muscle and Nerve 37(3): 396-398.
Trayner J, Nesbit G, Scott RM, Boulis NM, Selden NR. (2008) Clinical Problem Solving; Family Matters. Neurosurgery 62:195-201.
Khatib R, Ebrahim Z, Rezai A, Boulis NM, Doyle DJ, Schurigyn T, Farag E. (2008) Perioperative events during deep brain stimulation; The experience at the Cleveland Clinic. Anesthesia and Analgesia, 20(1): 36-40.
Rezai A, Machado A, Deogaonkar M, Azmi H, Kubu C, and Boulis NM. (2008) Surgery for Movement Disorders. Neurosurgery 62(2): Supp809-839. in Surgery of the Human Cerebrum.
Ugokwe K, Chahlavi A, Bingaman W, Gupta A, Prayson R, Boulis NM, Montes J. (2008) Clinical Problem Solving; Seize the Day. Neurosurgery 62:481-488.
Lopez-Gonzalez M, Riley J, Boulis NM, Burchiel K. (2008) Clinical Problem Solving; Lightning Strikes. Neurosurgery, 62(3): 724-734.
Toms S, Weil RJ, Prayson R, Boulis NM, Lang F. (2008) Clinical Problem Solving, Island Intruder. Neurosurgery 62(4): 920-927.
Ranalli NJ, Zager EL, McGarvey M, Boulis NM, Kline DG. (2008) Clinical Problem Solving: Brachial Plexus Closed Injury and Reconstruction. Neurosurgery,62(6): 1330-9.
Spiotta AM, Bain MA, Deogaonkar M, Hammert W, Boulis NM, Rezai A. (2008) Methods of scalp revision for deep brain stimulator hardware; the Good, the Bad, and the Ugly. Neurosurgery 62(3 Supp 1): 249-50.
Carlton E, Teng Q, Federici T, Yang J, Riley J, Boulis NM. (2008) Retrograde axonal transport and neuroprotection of a fusion protein containing the tetanus toxin C fragment binding domain and Bcl-xL. Neurosurgery 63(6): 1175-1184.
Federici T, Kutner R, Tordo N, Garrity-Moses M, Boulis NM, Reiser J. (2009) Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer. Genetic Vaccines and Therapy 7: 1
Federici T, Riley J, Park J, Bain M, Boulis NM. (2009) Preclinical safety and validation of a stabilized viral vector direct injection approach to the cervical spinal cord. Clinical and Translational Science 2 (2): 165-7.
Franz C, Federici T, Yang J, Backus C, Teng Q, Bishop K, Bartus R, Feldman EL, Boulis NM. (2009) Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS. Neurobiology of Disease 33(3): 473-481.
Bragg TM, Scianna J, Kassam A, Emami B, Brown HG, Hacein-Bey L, Clark JI, Muzaffar K, Boulis NM, Prabhu VC. Clinicopathological Review: Esthesioneuroblastoma. Neurosurgery 64(4): 764-770.
Henderson JM, Federici T, Boulis NM. (2009) Optogenetic neuromodulation. Neurosurgery 64(5): 796-804.
Non-Peer Review Book Chapters and Review Articles
Armstrong WS, Boulis NM, McGillicuddy JE. Infections of the Central Nervous System. In Crockard A, Hayward R, Hoff JT ed. Neurosurgery the Scientific Basis of Clinical Practice IIIrd Edition. Boston: Blackwell Scientific, 2000; 757-783
Muraszko KM, Boulis NM, Turner DE. Tethered Cord Release. In Batjer HH and Loftus CM eds. Textbook of Neurological Surgery. Philadelphia: Lippincott-Raven Publishers, 2003.
McGillicuddy JE and Boulis NM. Techniques of Nerve Repair. in Neurosurgery, 3rd ed. (Wilkins and Rengenchary eds), accepted in 2002: Publishers canceled printing of the book in 2005.
Baker KB, Boulis NM, Montgomery EB, Rezai A. Target selection using microelectrode recordings. Microelectrode Recording in Movement Disorder Surgery. (Israel and Burchiel eds), Thieme, New York; pp138-151, 2004.
Rosenow JM, Boongird A, Boulis NM, Rezai A. Surgical procedure for STN Stimulation. In Brain Stimulation and Epilepsy (Luders H ed),Chap 26, 323-327.
Garrity-Moses M, Liu J, Boulis NM. Molecular Biology and Gene Therapy in the Treatment of Chronic Pain. In Neurosurgery Clinics of North America: Neuroaugmentation for Chronic Pain, (Henderson J ed) WB Saunders Co, Elsevier Pub.Vol 14(3): 419-435, 2003.
Kopell B and Boulis NM. Setting Up a Movement Disorder Surgery Practice. In Movement Disorder Surgery; The Essentials. (Bakay R ed) Thieme Pub in press.
Boulis NM, Rezai AR, Song DK. Thalamotomy. In Therapy of Parkinson's Disease. Third Edition 2004 (Lyons, Kollers and Pahwa ed), Chap 19; 247-266, 2004.
Steinmetz, MP, Liu, JK, Boulis, NM. Cellular and Gene Therapy Approaches to Spinal Cord Injury. In Molecular Neurosurgery. (Freese, Simeone, Janson and Leone eds) Karger Publishers, Prog Neurolo Surg, pp 65-103, 2005.
Borsellino SR, Lastra JJ, Boulis NM, Benzel EC. Surgical exposure of peripheral nerves of the upper extremity Part I-Median Nerve. In Neurosurgical Operative Atlas (Rengenchary SS, Wilkins RH eds) AANS Publication Committee, in press.
Borsellino SR, Lastra JJ, Boulis NM, Benzel EC. Surgical exposure of peripheral nerves of the upper extremity Part II- Radial Nerve. In Neurosurgical Operative Atlas (Rengenchary SS, Wilkins RH eds) AANS Publication Committee, in press.
Teng Q, Federici T, Boulis NM. Viral vector axonal uptake and retrograde transport: Mechanisms and Applications. In Gene Therapy and the Brain (Kaplitt M and During MJ eds) WB Saunders Co, Elsevier Pub, pp 253-267, 2005.
Alexopoulos AV, Gonugunta V, Yang J, and Boulis NM. Electrical stimulation and gene-based neuromodulation for control of medically-refractory epilepsy. In Operative Neuromodulation (Sakas, Simpson, Kranes eds), Acta Neurochir Suppl 97(2): 293-309, 2007.
Riley J and Boulis NM. Molecular mechanisms of pain: A basis for chronic pain and therapeutic approaches based on the cell and the gene. Clinical Neurosurgery Vol 53: 67-98, 2006.
Tsao B, Boulis NM. Peripheral Nerve Trauma. Neurology in Clinical Practice, 5th Edition. (Bradley WG, Daroff RB, Fenichel GM, Jankovic J eds.) Butterworth Heineman, Philadelphia, pp1145-1164.
Riley J, Spiotta A, and Boulis NM. Experimental Advances in Tumors of the Peripheral Nervous System. In Neurosurgery Focus (Kline D and Tiel R eds). 22(6): E2, 2007.
Federici T and Boulis NM. The relevance of molecular targeting and therapeutics to neurosurgical practice (RNAi). Clinical Neurosurgery Vol 54: 110-117, 2007.
Riley J, Sweeney W, Boulis NM. Shifting the balance: cell-based therapeutics as modifiers of the amyotrophic lateral sclerosis-specific neuronal microenvironment. In Neurosurgery Focus: Stem Cells and Central Nervous System Therapeutics (Selden ed). AANS Pub, Neurosurg Focus 24 (3&4): E9, 1-13, 2008.
Federici T, Riley J & Boulis N. Gene-Based Neuromodulation. Textbook of Neuromodulation. 2009. (Krames E, Peckham H, and Rezai eds.). Elsevier Science, 2009.
Abstracts
Boulis NM, Kim HM, Mian FS, Hoff JT. Urinary retention following routine neurosurgical spinal procedures. (2000) Abstracts of the American Association of Neurological Surgeons: 98
Boulis NM, Turner DE, Imperiale MJ. Creation of two adenoviral vectors for stereotactic insulin-like growth factor I gene therapy. (2000) Abstracts of the American Association of Neurological Surgeons: 116
Boulis NM, Noordmans AJ, Feldman EL, Imperiale MJ. (2000) Adeno-associated viral gene expression in the adult rat spinal cord following remote vector delivery. Molecular Therapy 1(5): S110-S111
Noordmans AJ, Hilgendorf A, Boulis NM, Imperiale MJ. (2000) Prolonged gene expression following direct spinal cord injection of AdLAPAP in the adult rat. Molecular Therapy 1(5): S111
Boulis NM, Gong C, Jun G, Turner DE, Hoff JT, Keep RF. DNA fragmentation and Caspace-3 activation following intracerebral hemorrhage. (2000) Congress of Neurological Surgeons
Boulis NM, Muraszko KM. Project Shunt: A model for collaborative efforts in the developing world. (2001) Abstracts of the American Association of Neurological Surgeons: 148
Boulis NM, Noordmans AJ, Feldman EL, Imperiale MJ. Adeno-associated viral vectors enhance central nervous system gene delivery with remote injection. (2001) Abstracts of the American Association of Neurological Surgeons: 198
Rubin AD, Hogikyan N, Boulis NM, Sullivan K, Feldman EL. Remote delivery of rAAV-GFP to the rat brainstem via the recurrent laryngeal nerve. (2001) Neuroscience Abstracts: 871.3.
Noordmans AJ, Song DK,. Noordmans CJ, Boulis NM. Adeno-associated viral gene expression in the lateral nucleus of the rat hypothalamus. (2001) Neuroscience Abstracts: 246.8.
Song DK, Boulis NM, Noordmans AJ, Erikson NA, Russell JR*, Feldman EL. Remote adeno-associated viral gene delivery to the spinal cord and dorsal root ganglion in streptozotocin-treated mice. (2001) Neuroscience Abstracts: 361.5.
Boulis NM, Russell JW, Song DK, Noordmans AJ, Feldman EL. Toward a biological surgery for diabetic neuropathy. Abstracts of the Congress of Neurological Surgeons (2001)
Boulis NM, Noordmans AJ, Song DK, Feldman EL. Stereotactic gene based hypothalamic neuromodulation. Abstracts of the American Association of Neurological Surgeons (2002)
Vincent AM, Boulis NM, Jung V, Song DK, Imperiale MJ, Feldman EL. AAVCMV.IGF-I.IRES.GFP based neuroprotection in an in vitro model of Amyotrophic Lateral Sclerosis. Molecular Therapy 5(5):S96. (2002).
Boulis NM, Erikson N, Song DK, Imperiale MJ. Intraneural colchicine inhibits remote spinal cord delivery of adenovirus and AAV. Molecular Therapy 5(5):S300, (2002).
Watson P, Montgomery EB, Baker KB, Rezai A, Boulis NM, Henderson J. Subthalamic nucleus (STN) neuronal activity in meaningful and non-meaningful speech. Abstracts of The Movement Disorder Society, in press.
Schuele SU, Kellinghaus C, Bethoux FA, Boulis NM, Loddenkemper T. Frequency of seizures in Multiple Sclerosis Patients treated with intrathecal baclofen. Abstracts of the American Epilepsy Society, in press.
Rosenow J, Boulis N, Analysis of Infections in Implanted Deep Brain Stimulation hardware. (2003) Abstracts of the American Association of Neurological Surgeons
Qinshan T, Garrity-Moses M, Boulis NM. Adeno-associated virus-mediated gene transfer of BclX L for motor neuron protection. (2003) CWRU Research ShowCASE.
Garrity-Moses ME, Qingshan T, Tanase D, Liu J, Bhat M, Boulis NM. (2003) AAVCMV.Bcl-xLGFP gene delivery to SHSY5Y neuroblastoma cells as a neuroprotective agent in glutamate-induced apoptosis. Molecular Therapy 7(5): S96.
Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Mazarakis N*, Boulis NM. (2003) Techniques for Remote Cervical Spinal Cord Delivery of Neurotherapeutic RabG-EIAV Encoded Genes. Molecular Therapy 7(5): S97.
Liu JK, Qingshan T, Garrity-Moses ME, Tanase D, Imperiale MJ, Boulis NM. Strategy for the development of neurotropic AAV: biopanning for neurotropic peptides. Molecular Therapy 2003 7(5): S351.
Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. (2003) Gene Based Model for the Development of Countermeasures to Clostridial Bioterrorism. Molecular Therapy 7(5): S97.
Garrity-Moses ME, Teng Q, Tanase D, Liu J, Rezai A, Boulis NM. (2003) AAV.CMV.Bcl-xL-GFP Motor Neuron Protection Against Excitotoxicity In Vitro. Neuroscience Abstracts 789.1.
Liu J, Teng Q, Tanase D, Garrity Moses ME, Baker K*, Boulis NM. (2003) Short Peptides with Clostridial Ganglioside Binding Properties Defined through Phage Display. Neuroscience Abstracts 495.6.
Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. (2003) Synaptobrevin digestion in vitro with a tetanus light chain adenoviral vector. Neuroscience Abstracts 54.5.
Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Boulis NM. (2003) In vivo synaptic inhibition through intracellular tetanus light chain expression. Neuroscience Abstracts 900.5.
Garrity-Moses ME, Boninsegna S, Teng Q, DalToso R, Boulis NM, Albensi BC * and Janigro D. (2003) Biosil encapsulation of mammalian cells: a novel strategy for cell-mediated drug delivery. Neuroscience Abstracts 789.1.
Cooper SE, Baker K, Boulis NM, Henderson J, Rezai A, Montgomery EB, Grill WM. (2003) Paired pulse deep brain stimulation of thalamus in essential tremor: tremor suppression and paresthesias. Neuroscience Abstracts 97.20.v
Boulis NM, Teng Q, Liu J, Tanase D, Garrity-Moses M. Neurosurgical Gene-based Alternative to Deep Brain Stimulation and Botulinum Toxin. (2004) Abstracts of the American Association of Neurological Surgeons.
Liu J, Teng Q, Tanase D, Garrity Moses ME, Boulis NM. Neuronal membrane specific binding peptides isolated via phage display biopanning against trisialogangliosides.. Mol Therapy 9(Supp1): S167.
Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Mazarakis N, Walmsely L, Azzouz M, Boulis NM. Cervical spinal cord delivery of a lentiviral vector in SOD-1 transgenic mice. Mol Therapy 9(Supp1): S201.
Teng Q, Garrity-Moses M, Liu J, Tanase D, Mazarakis N, Azzouz M, Walmsely L, Boulis NM. EIAV-IGF-I Gene Transfer to Motor Neurons Enhances Axonal Length in Vitro. Mol Therapy 9(Supp1): S280.
Krishnaney A, Zhao Z, Teng Q, Liu J, Garrity-Moses M, Davis M, Boulis NM. Adenoviral Light Chain Gene Expression in the Brainstem Induces Specific Motor Inhibition. Mol Therapy 9(Supp1): S19.
Pilitsis, JG, Rezai A, Boulis NM, Henderson JM, Busch RM, Kubu CS. Postoperative confusion following STN DBS predicts greater neuropsychological difficulties in the longterm: Preliminary Findings. (2005) American Association of Neurological Surgeons
Liu, JK, Tanase, D, Garrity-Moses, M, Teng, Q, Boulis NM Neuronal Binding of a Novel 12 AA Peptide Defined by Phase Display. Society for Neuroscience Abstract 876.9.
Tanase D, Teng Q, Liu JK, Garrity-Moses ME, Boulis NM Reversible Neuromuscular Inhibition Through Transient Spinal Cord Tetanus Light Chain Gene Expression. Society for Neuroscience Abstract 874.6
Garrity-Moses ME, Teng Q, Liu JK, Tanase D, Rezai A, Boulis NM. Adenoviral XIAP Expression Protects Motor Neurons In An In Vitro Model of Amyotrophic Lateral Sclerosis. Society for Neuroscience Abstract 312.10
Boulis NM, Garrity-Moses ME, Liu JK, Tanase D, Tang Q. EIAV-IGF-I Gene Transfer to Motor Neurons Enhances Motor Neuron Survival and Axonal Length. Society for Neuroscience Abstract 134.5
Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. AAVTET-ONLC: A Means For Controlled Synaptic Inhibition. Society for Neuroscience Abstract 12.4
Boulis NM, Yang, J, Teng Q, Garrity-Moses M, Tanase D. RabG.EIAV-IGF-I peripheral injection prolongs survival in a mouse ALS model through retrograde gene delivery. (2005) Abstracts of the American Association of Neurological Surgeons.
Boulis NM, Garrity-Moses M., Qingshan T. Development of anti-apoptotic gene transfer as a means for neuroprotection against excitotoxicity. (2005) Abstracts of the American Association of Neurological Surgeons.
Yang J, Teng Q, Garrity-Moses M, Federici T, Najm I, Chabardes S, Moffitt M, Boulis NM Gene therapy of epilepsy by adenovirus-mediated tetanus toxin light chain gene transfer. Molecular Therapy 11: (Suppl. 1) S168 #433, 2005.
Garrity-Moses M, Teng Q, Yang J, Federici T, Gilbert E, SubramanianT, Boulis NM Adenoviral clostridial light chain expression in the medial forebrain bundle: a reversible model of dopamine depletion. Molecular Therapy 11: (Suppl. 1) S405 #1050, 2005.
Teng Q, Federici T, Garrity-Moses M, Yang J, Reiser J, Boulis NM Neuronal gene transfer with HIV-1-based lentiviral vectors pseudotyped with lyssavirus glycoproteins. Molecular Therapy 11: (Suppl. 1) S187 # 482, 2005.
Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. In vivo spinal cord uptake and neuronal binding properties of Tet1: a potential means for enhanced spinal cord AAV delivery. Molecular Therapy 11: (Suppl. 1) S332 #855, 2005.
Davis A, Stachler M, Shi W, Liu JK, Boulis NM, Bartlett JS. Manipulating AAV2 tropism for enhanced delivery of AAV vectors to the spinal cord. Molecular Therapy 11 (Suppl. 1) S46, #113, 2005.
Liu JK, Federici T, Boulis NM. (2005) Novel Neuronal Membrane Targeted 12 Amino Acid Peptides Defined Through Phage Display. 9th International Conference on Neural Transplantation and Repair.
Boulis NM, Yang J, Teng Q, Najm I, Chabardes S, Moffit, Garrity-Moses M. Light Chain Gene-based Control of neocortical epilepsy. Abstracts of the Congress of Neurological Surgeons, 2005.
Liu JK, Federici T, Teng Q, Garrity-Moses M, Yang J, Tanase D, Boulis NM. In vivo neuronal bindig properties of Tet1: a peptide isolated from a random 12mer phage display library. Society for Neuroscience Abstract 229.17, 2005.
Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. Phage display identification of C7C loop peptide with neuronal affinity. Society for Neuroscience Abstract 229.10, 2005.
H. Kuroda, Teng Q, Garrity-Moses M, Federici T, Yang J, Kutner R, Tordo N, Carlton E, Krudy C, Reiser J, Boulis NM. Pseudotyping HIV-1 based lentiviral vectors with lyssavirus glycoproteins for neuronal gene transfer. Society for Neuroscience Abstract 228.15, 2005.
Yang J, Teng Q, Garrity-Moses MG, Federici T, Najm I, Chabardes S, Moffitt M, Alexopoulos A, Riley J, Boulis NM. Cortical clostridial light chain gene-based synaptic inhibition inhibits neocortical seizures. Society for Neuroscience Abstract 244.11, 2005.
Garrity-Moses MG, Teng Q, Gilbert E, Yang J, Federici T, Boulis NM. Synaptobrevin digestion results in dopamine depletion in the medial forebrain bundle. Society for Neuroscience Abstract 494.7, 2005.
Hayek S, Henderson J, Boulis N, Kapural L, Stanton-Hicks M, Nagy M. Peripheral nerve stimulation for post surgical facial neuralgias. Program and abstracts of the 21st Annual Meeting of the American Academy of Pain Medicine; February 23-27, 2005; Palm Springs, California. Abstract 105.
Teng Q, Bartlett JS, Federici T, Yang J, Boulis NM. Tetanus toxin heavy chain-streptavidin fusion protein targeted motor neuron gene delivery through metabolically biotynilated AAV. Molecular Therapy 13(S1), S193, 2006.
Yang J, Qingshan T, Federici T, McClelland S III, Boulis NM. Hemiparkisonism induced through unilateral expression of Adenovirus-mediated clostridial light chain gene in the Substantia Nigra. Molecular Therapy 13(S1), S92, 2006.
Boulis NM, Federici T, Garrity-Moses M, Krudy C, Teng Q, Yang J. Adenovirus-light chain inhibition of growth hormone release from pituitary adenoma cells. Molecular Therapy 13(S1), S54, 2006.
Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. Neuronal affinity of a C7C Loop peptide identified through phage display. Molecular Therapy 13 (S1), S195, 2006.
Ford PJ, Deshpande A, Boulis NM, Murphy C, Benzel EC. Teaching Ethics: A review of resident's ethics cases. Select Abstract; Congress of Neurological Surgeons 2006.
Qingshan T, Federici T, Yang J, Bartlett J, Boulis NM. Targeted motor neuron and dorsal root ganglion gene delivery through tetanus toxin heavy chain-Streptavidin fusion protein and metabolically biotinylated AAV. Congress of Neurological Surgeons 2006.
Qingshan T, Federici T, Yang J, Boulis NM. Tetanus toxin heavy chain-Bcl-xL fusion proteins for targeted gene therapy of motor neuron diseases. Society for Neuroscience Abst. 708.5, 2006.
Yang J, Garrity-Moses M, Federici T, Qingshan T, Boulis NM. Clostridial light chain expression in the substantia nigra induces a reversible hemiparkinsonism in the rat. Society for Neuroscience Abst. 675, 2006.
McClelland S III, Bethoux FA, Sutliff MH, Stough DK, Schwetz KM, Gogol DM, Harrison M, Pioro EP, Boulis NM. (2007) Intrathecal baclofen for spasticity-related pain in Amyotrophic Lateral Sclerosis: Efficacy and facts associated with pain relief. Abstracts of the American Association of Neurological Surgeons.
Yang J, Carlton E, Federici T, Bishop KM, Backus C, Oh SS, Teng Q, Riley J, Gasmi M, Bartus RT, Feldman EL, Boulis NM. (2007) AAV-mediated IGF-1 delivery to the cervical spinal cord of the SOD1 rat model of ALS via intraparenchymal Injection. Mol Therapy 15(S1): S260.
Federici T, Kutner RH, Tordo N, Yang J, Carlton E, Boulis NM, and Reiser J. Cell Targeting in the CNS Using HIV-1-based lentiviral vectors bearing alternate glycoproteins and promoters. Mol Therapy 15(S1): S205.
Federici T, Davis A, Teng Q, Riley J, Bartlett JS, and Boulis NM. (2007) Genetic modification of AAV1 capsid for MN targeted gene delivery. Mol Therapy 15(S1): S31.
Teng Q, Carlton E, Katakam A, Kumar P, Yang J, Federici T, Riley J, Crest D, Boulis NM. (2007) Controlled Expression of an Inwardly-Rectifying Potassium Channel for Neuromodulation. Mol Therapy 15(S1): S107.
Deogaonkar M, Boulis N, Henderson JM, Machado A, Azmi H, Senatus P, Rezai AR. (2007) Surgical complications in 800 consecutive DBS Implants. American Association of Neurological Surgeons Abstracts.
Deogaonkar M, Machado M, Rezai A, Boulis N. (2007) Accuracy of targeting using a frameless stereotactic targeting system for deep brain stimulation surgery. Congress of Neurological Surgeons Abstracts.
Riley J, Park J, Teng Q, Yang J, Federici T, and Boulis N. (2007) Development and Pre-Clinical Safety Validation of a Stabilized Intraspinal Microinjection Platform. International Society for Reconstructive Neurosurgery.
Teng Q, Katakam AK, Yang J, Riley J, Federici T, Franz C, Kumar P and Boulis NM. (2008) Suppression of the rat hindlimb motor function through RheoReceptor inducible expression of Kir2.1 in the lumbar spinal cord. Mol Ther, 16(Supp 1): S193.
Federici T, Riley J, Park J, Teng Q, Franz C, Boulis NM. (2008) Targeted microinjection of AAV2-GFP in the cervical spinal cord for clinical translation. Mol Ther 16(Supp 1): S243-244.
Franz CK, Krudy C, Federici T, Teng Q, Yang J, Boulis NM. (2008) Direct spinal cord injection of AAV2-mediated insulin-like growth factor 1 or vascular endothelial growth factor in a rat model of ALS. Mol Ther 16(Supp 1): S289.
Riley J, Park JJ, Federici T, Bain MD, Teng Q, Franz C, Bartus R, Boulis NM (2008) Preclinical safety validation of a stabilized microinjection approach for viral therapeutics delivery to the ventral horn. Congress of Neurol Surgeons Online Abstracts.
Franz, C.K., Krudy, C., Federici, T., Boulis, NM (2008) The effects of conditioning nerve lesions on disease progression in a rat model of familial amyotrophic lateral sclerosis. Society for Neuroscience Annual Meeting Washington, DC. Program Number 643.14.
Federici T, Raore B, Taub J, Johe K, Boulis N, Human Neural Stem Cell Grafts for Amyotrophic Lateral Sclerosis (ALS) Segmental Treatment: Preclinical Safety and Toxicity Data in Miniature Swine. Cell Transplantation, p 6, 2009. (16th Annual Meeting- American Society of Neural Therapy and Repair).
Barker F, Connolly S, Hoh B, Selden N, Kondziolka D, Asher A, Boulis NM. (2009) Community and Individual Equipoise for Ruptured Intracranial Aneurysm Clipping versus Coiling: Results from Interactive Medical Learning(SM) (IML). Congress of Neurological Surgeons Abstracts
Deogaonkar M, Machado A, Boulis NM. (2009) Peripheral Nerve Stimulation for Chronic Pain - One Institution's Experience. Congress of Neurological Surgeons Abstracts
Siffert J, Marks WJ, Starr PA, Stacy MA, Boulis NM, Vitek JL, Verhagen RL, Watts RL, Jankovic J, Tagliati M, Stern MB, Nutt JG, Kordower JH, Olanow CW, Bartus RT. (2009) AAV2-Neurturin (CERE120) for advanced parkinson's disease (PD): Efficacy and Safety results from a controlled Phase 2 clinical trial. Society for Neuroscience Abstracts.
Baum GR, Federici T, Leung C, Taub JS, Boulis N. Direct Spinal Cord Gene Therapy with C3 Transferase in a Mouse Model of Amyotrophic Lateral Sclerosis. Georgia Neurosurgical Society Winter Meeting Oral Presentation, Atlanta, Georgia: Winter 2010.
Taub JS, Baum G, Federici T, Boulis N. Intrathecal Spinal Cord Gene Delivery for Spinal Muscular Atrophy. American Association of Neurological Surgeons Annual Meeting Oral Presentation, Denver, Colorado: Spring 2011.
