Malignant Fibrous Histiocytoma (MFH)

Malignant fibrous histiocytoma is the most common malignant soft tissue tumor in late adulthood. The most common location is in the lower limbs, particularly the thigh region, where it can appear as a painless mass. Less frequently, it can grow in the abdomen and be undetected until the patient starts to develop symptoms related to an increase in abdominal pressure, such as bloating, frequent urination or constipation. There have been some reports of malignant fibrous histiocytoma developing in patients who received high-doses of radiation for many years in the past, and other reports suggest a viral or a chemical cause. In most cases, the origin is not known.

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