Specialties

Pathology

Anatomic Pathology (Board certified since 1997)

Neuropathology (Board certified since 1999)

At a Glance

  • 1997 Started practicing
  • 20 Years experience
  • 1 OFFICE LOCATION
  • 2 HOSPITAL AFFILIATIONS

About Dr. Brat

My Clinical Interests

  • brain tumors
  • Spine Tumor

Academic Profile

Training

MEDICAL SCHOOL

Mayo Medical School, Rochester, MN

INTERNSHIP

Johns Hopkins Hospital, Baltimore, MD

RESIDENCY

Johns Hopkins Hospital, Baltimore, MD

FELLOWSHIP

Johns Hopkins Hospital, Baltimore, MD

Professional Memberships

American Society of Clinical Investigation (ASCI), 2014

Board of Directors, Society for Neuro-oncology (SNO), 2013

Executive Council, American Association of Neuropathologists (AANP), 2013

Chair, Neuropathology Committee, College of American Pathologists (CAP), 2012

Honors & Awards

Distinguished Cancer Scientist
Georgia Research Alliance (GRA), 2010

Lucien J. Rubinstein Award
American Association of Neuropathologists, 2004

Benjamin Castleman Award
United States and Canadian Academy of Pathology, 2000

Major Publications

The Cancer Genome Research Network (2013). The somatic genomic landscape of glioblastoma. Cell 155:462-477.

Chen G, Kong J, Tucker-Burden C, Anand M, Rong Y, Rahman F, Moreno CS, Van Meir EG, Hadjipanayis CG, Brat DJ. (2014) Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma. Cancer Res. 74:4536-48.

Cooper LA, Gutman DA, Chisolm C, Appin C, Kong J, Rong Y, Kurc T, Van Meir EG, Saltz JH, Moreno CS, Brat DJ. (2012) The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma Am J Pathol 180:2108-19.

Appin CL, Brat DJ. (2014) Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis Adv Anat Pathol 22:50-58.

Brat DJ, Ryken TC, Kalkanis SN, Olson JJ. (2014) The role of neuropathology in the management of progressive glioblastoma: A systematic review and evidence-based clinical practice guideline. J. Neurooncol. 118:461-78

“Pseudopalisading” necrosis in glioblastoma: a familiar morphologic finding that links vascular pathology, hypoxia, and angiogenesis. J. Neuropathol. Exp. Neurol, 65:529-39.

The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas. PloS One, 5:e10849.

EGFR and PTEN modulate tissue factor expression in glioblastoma through JunD/AP-1 transcriptional activity. Cancer Res, 69:2540-49.

Locations & Appointments

1 Office Location(s)

1

Pathology Department

Emory University Hospital
1364 Clifton Rd NE
Ste H176
Atlanta, GA 30322
  • 404-712-1266
S

2 Hospital Affiliation(s)

2

Emory University Hospital

1364 Clifton Rd NE
Atlanta, GA 30322
H
3

Emory University Hospital Midtown

550 Peachtree St NE
Atlanta, GA 30308
H

Academic Profile

Training

MEDICAL SCHOOL

Mayo Medical School, Rochester, MN

INTERNSHIP

Johns Hopkins Hospital, Baltimore, MD

RESIDENCY

Johns Hopkins Hospital, Baltimore, MD

FELLOWSHIP

Johns Hopkins Hospital, Baltimore, MD

Professional Memberships

American Society of Clinical Investigation (ASCI), 2014

Board of Directors, Society for Neuro-oncology (SNO), 2013

Executive Council, American Association of Neuropathologists (AANP), 2013

Chair, Neuropathology Committee, College of American Pathologists (CAP), 2012

Honors & Awards

Distinguished Cancer Scientist
Georgia Research Alliance (GRA), 2010

Lucien J. Rubinstein Award
American Association of Neuropathologists, 2004

Benjamin Castleman Award
United States and Canadian Academy of Pathology, 2000

Major Publications

The Cancer Genome Research Network (2013). The somatic genomic landscape of glioblastoma. Cell 155:462-477.

Chen G, Kong J, Tucker-Burden C, Anand M, Rong Y, Rahman F, Moreno CS, Van Meir EG, Hadjipanayis CG, Brat DJ. (2014) Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma. Cancer Res. 74:4536-48.

Cooper LA, Gutman DA, Chisolm C, Appin C, Kong J, Rong Y, Kurc T, Van Meir EG, Saltz JH, Moreno CS, Brat DJ. (2012) The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma Am J Pathol 180:2108-19.

Appin CL, Brat DJ. (2014) Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis Adv Anat Pathol 22:50-58.

Brat DJ, Ryken TC, Kalkanis SN, Olson JJ. (2014) The role of neuropathology in the management of progressive glioblastoma: A systematic review and evidence-based clinical practice guideline. J. Neurooncol. 118:461-78

“Pseudopalisading” necrosis in glioblastoma: a familiar morphologic finding that links vascular pathology, hypoxia, and angiogenesis. J. Neuropathol. Exp. Neurol, 65:529-39.

The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas. PloS One, 5:e10849.

EGFR and PTEN modulate tissue factor expression in glioblastoma through JunD/AP-1 transcriptional activity. Cancer Res, 69:2540-49.