Daniel Brat, MD, PhD

Daniel  Brat, MD, PhD
Emory Clinic

Professor of Pathology and Laboratory Medicine

Emory Healthcare Network Physician
Specialties:
Neuropathology (Board certified since 1999)
Pathology (Board certified since 1997)
Office(s) Locations:
Emory Univ Hosp-Path Dept.
1364 Clifton Rd Ste H176
Atlanta, GA 30322
(404) 712-1266
Year Started Practicing at Emory: 1999
Organizational Memberships:
American Society of Clinical Investigation (ASCI), 2014
Board of Directors, Society for Neuro-oncology (SNO), 2013
Executive Council, American Association of Neuropathologists (AANP), 2013
Chair, Neuropathology Committee, College of American Pathologists (CAP), 2012
Major or Recent Publications:

The Cancer Genome Research Network (2013). The somatic genomic landscape of glioblastoma. Cell 155:462-477.

Chen G, Kong J, Tucker-Burden C, Anand M, Rong Y, Rahman F, Moreno CS, Van Meir EG, Hadjipanayis CG, Brat DJ. (2014) Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma. Cancer Res. 74:4536-48.

Cooper LA, Gutman DA, Chisolm C, Appin C, Kong J, Rong Y, Kurc T, Van Meir EG, Saltz JH, Moreno CS, Brat DJ. (2012) The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma Am J Pathol 180:2108-19.

Appin CL, Brat DJ. (2014) Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis Adv Anat Pathol 22:50-58.

Brat DJ, Ryken TC, Kalkanis SN, Olson JJ. (2014) The role of neuropathology in the management of progressive glioblastoma: A systematic review and evidence-based clinical practice guideline. J. Neurooncol. 118:461-78

“Pseudopalisading” necrosis in glioblastoma: a familiar morphologic finding that links vascular pathology, hypoxia, and angiogenesis. J. Neuropathol. Exp. Neurol, 65:529-39.

The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas. PloS One, 5:e10849.

EGFR and PTEN modulate tissue factor expression in glioblastoma through JunD/AP-1 transcriptional activity. Cancer Res, 69:2540-49.

Awards:
Distinguished Cancer Scientist
Georgia Research Alliance (GRA), 2010

Lucien J. Rubinstein Award
American Association of Neuropathologists, 2004

Benjamin Castleman Award
United States and Canadian Academy of Pathology, 2000
Education:
Medical School
Mayo Medical School, Rochester, MN

Internship
Johns Hopkins Hospital, Baltimore, MD

Residency
Johns Hopkins Hospital, Baltimore, MD

Fellowship
Johns Hopkins Hospital, Baltimore, MD