Christian Larsen, MD Phil

Christian  Larsen, MD Phil
Emory Clinic

Dean, Emory University School of Medicine

Vice President for Health Center Integration, Woodruff Health Sciences Center

Chair, Board of Directors, The Emory Clinic

Professor of Surgery, Division of Transplantation, Department of Surgery

Emory Healthcare Network Physician
Specialties:
Transplantation
Surgery (Board certified since 1992)
Areas of Clinical Interest:
islet transplantation
kidney transplant
pancreatic transplantation
Office(s) Locations:
Emory University Hospital
1364 Clifton Road, B-206
Atlanta, GA 30322
(404) 727-0717
Hospital Affiliation(s):
Emory University Hospital
About Dr. Larsen

In 2003, he performed the first islet transplant in Georgia. In addition to maintaining this busy surgical and clinical schedule throughout his career, he has built one of the foremost transplantation immunology programs in the world.

Dr. Larsen was the first to demonstrate the migration of Dendritic cells, so-called sentinels of the immune system, from the transplanted organ to the draining lymph node or spleen, where they initiate the immune response that causes allograft rejection. In a seminal publication in Nature in 1996, he provided unequivocal evidence that blocking T lymphocyte costimulation at the time of transplantation guarantees long-term survival of organ allografts in rodents. These findings were rapidly translated by Dr. Larsen's research group to primates and later to humans, and are currently a clinically proven treatment for recipients of solid organ transplants.

His current scientific endeavors are focused on achieving immunological tolerance through the induction of mixed hematopoietic chimerism and on the application of costimulation blockers to facilitate transplantation of insulin-producing cells, islets, to treat type 1 diabetes.

Dr. Larsen's achievements are distinguished by his talent to successfully drive a discovery from the bench to the bedside using the rigor of the scientific method.

Year Started Practicing: 1990
Year Started Practicing at Emory: 1990
Organizational Memberships:
American Association of Immunologists
American College of Surgeons, Fellow (FACS)
American Diabetes Association
American Society for the Advancement of Science
American Society of Transplant Surgeons
American Society of Transplantation
Georgia Transplant Foundation
International Pancreas and Islet Transplant Association
The National Kidney Foundation
The Society of Clinical Surgery
Major or Recent Publications:

Bray, R.A., D.L. Nolen, C. Larsen, T. Pearson, K.A. Newell, K. Kokko, A. Guasch, P. Tso, J.B. Mendel, and H.M. Gebel. 2006. Transplanting the highly sensitized patient: the Emory algorithm. Am J Transplant,6:2307-2315.

Ford ML, and C.P. Larsen. 2009. Translating costimulation blockade to the clinic: lessons learned from three pathways. . Immunol Rev May,229(1):294-306.

Gangappa, S., K.E. Kokko, L.M. Carlson, T. Gourley, K.A. Newell, T.C. Pearson, R. Ahmed, and C.P. Larsen. 2008. Immune responsiveness and protective immunity after transplantation. Transplant Int Apr,21:293-303.

Larsen, C.P., S.J. Knechtle, A. Adams, T. Pearson, and A.D. Kirk. 2006. A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. Am J Transplant,6:876-883.

Larsen, C.P., T.C. Pearson, A.B. Adams, P. Tso, N. Shirasugi, E. Strobertm, D. Anderson, S. Cowan, K. Price, J. Naemura, J. Emswiler, J. Greene, L.A. Turk, J. Bajorath, R. Townsend, D. Hagerty, P.S. Linsley, and R.J. Peach. 2005. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant,5:443-453.

Newell, K.A., C.P. Larsen, and A.D. Kirk. 2006. Transplant tolerance: converging on a moving target. Transplantation,81:1-6.

Newell, K.A., and C.P. Larsen. 2006. Tolerance assays: measuring the unknown. Transplantation,81:1503-1509.

Newell, K.A., and C.P. Larsen. 2006. Toward transplantation tolerance: a large step on a long road. Am J Transplant,6:1989-1990.

Newell, K.A., and C.P. Larsen. 2007. Transplantation tolerance. Seminars in Nephrology,27:487-497.

Vincenti, F., C.* Larsen, A. Durrbach, T. Wekerle, B. Nashan, G. Blancho, P. Lang, J. Grinyo, P.F. Halloran, K. Solez, D. Hagerty, E. Levy, W. Zhou, K. Natarajan, and B. Charpentier. 2005. Costimulation blockade with belatacept in renal transplantation. The New England Journal of Medicine,353:770-781.

Awards:
AST-Roche Basic Science Established
Investigator Award, American Society of Transplantation, 2004

Dean’s Clinical Investigator Award,
Emory University School of Medicine, 2002-2003

Dean’s Clinical Investigator Award,
Emory University School of Medicine, 1999-2000

Dean’s Distinguished Faculty Lecture
and Award, Emory University School of Medicine, 2009

Emory University - Great Teachers Lecture
2002

NIH Basic Science Award,
American Society of Transplant Physicians, 1997

TTS-Roche Award for Excellence
in Translational Science, The Transplantation Society, 2006

Thomas E. Starzl Prize in Surgery
and Immunology, University of Pittsburgh, 2007
Education:
Medical School
Emory University School of Medicine, Atlanta, GA

Residency
Emory University Affiliated Hospital, Atlanta, GA

Fellowship
University of Oxford, Oxford, UK
Emory University Hospital, Atlanta Georgia
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Call 404-778-7777 for more information.