Emory Interventional Cardiology Clinical Trials Currently Recruiting Patients

THE PARTNER I and II TRIALS

Purpose: To determine the safety and effectiveness of novel treatment delivery systems in high-risk, symptomatic patients with severe aortic stenosis..
Principal Investigators: Drs. Babaliaros, Block, Vinod Thourani and Robert Guyton

VIVID: Valvular and Ventricular Improvement Via iCoapsys Delivery – Feasibility Study

Purpose: The purpose of this prospective, non-randomized, single-arm feasibility study is to evaluate the safety and feasibility of the iCoapsys System in patients with functional mitral valve insufficiency caused by annular dilation and/or papillary muscle displacement.
Principal Investigator: Dr. Block

Evaluation of the Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture-Prone Coronary Plaques

Principal Investigator: Dr. Samady

FAME II – Fractional Flow Reserve (FFR)-Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Versus OMT Alone

Purpose: To compare the clinical outcomes, safety and cost-effectiveness of FFR-guided PCI plus OMT with those OMT alone in patients with stable coronary artery disease.
Physician Investigator: Dr. Samady

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Mobilization of Progenitor Cells in Peripheral Arterial Disease (GPAD-2)

Purpose: This study will test whether treatment with the drug GM-CSF will improve symptoms and signs of peripheral arterial disease better than placebo with four weeks of therapy. This study also will examine whether improvements in blood vessel function are observed. Finally, the study will measure blood vessel function and stem cell levels in order to determine if they can help predict whether patients with peripheral arterial disease will suffer further cardiovascular complications.
Principal Investigator: Dr. Arshed Quyyumi
Sub-Investigators: Drs. Edmund Waller, Robert Taylor, John Oshinski and Elliot Chaikof

Endovascular Atherectomy Safety and Effectiveness (EASE) Study: A Prospective, Multicenter Clinical Evaluation of the Safety and Effectiveness of the Phoenix Atherectomy™ System in Atherectomy of the Peripheral Vasculature

Purpose:  To evaluate the procedural safety and effectiveness of the Phoenix Atherectomy System for treatment of de novo and restenotic atherosclerotic lesions causing blockages in the lower extremity. This is an investigational device, and only a few sites in the country are involved in this trial.
Physician Investigators: Drs. Niazi, Devireddy and McDaniel

Peripheral Facilitated Antegrade Steering Technique – Chronic Total Occlusions (PFAST-CTOs) Clinical Study

Purpose: To demonstrate the ability of the BridgePoint Medical System to facilitate the safe and effective intraluminal placement of guidewires beyond peripheral CTOs without significant increases in major adverse events. This is an investigational study being performed at only a few sites nationwide.
Physician Investigators: Drs. Niazi, Devireddy and McDaniel

FREEDOM: GORE® Flow Reversal System and GORE® Embolic Filter Extension Study for the Ongoing Collection of Patient Outcomes

Purpose: To provide an ongoing evaluation of clinical outcomes associated with the GORE Flow Reversal System and the GORE Embolic Filter when used for embolic protection during carotid artery stenting.
Physician Investigators: Drs. Niazi and Devireddy

For more details on any of these trials, call the Emory Physician Consult Line at 404-778-5050 or 1-800-22-EMORY or visit clinicaltrials.gov and search for the trial name.