Stuart J. Knechtle, MD - Basic Science Research Faculty

Stuart J. Knechtle, MD

Professor, Department of Surgery
The Emory Clinic and Hospital
Surgical Director, Liver Transplantation
Clinical Director, Emory Transplant Center

Dr. Knechtle joined the Emory Transplant Center as the Liver Transplant Surgical Director in July, 2008.  Dr. Knechtle received his AB from Princeton University in 1978 and his MD from Cornell University Medical College in 1982. He continued his education as a resident in surgery and research fellow in transplant immunology at Duke University and a transplant fellow at the University of Wisconsin. Dr. Knechtle was most recently Ray D. Owen Professor of Transplantation and Director of Liver Transplantation at the University of Wisconsin. Knechtle led a team that performed Wisconsin’s first liver transplant from a living donor and the state’s first combined liver/pancreas transplant.

He is a member of numerous professional societies including American Society of Transplant Surgeons, American Society of Transplantation, The Transplantation Society, Society of University Surgeons, Central Surgical Association, American Surgical Association, and Society of Clinical Surgery. In 1999, Dr. Knechtle was a James IV Association Traveling Fellow. He is on the editorial board of several national academic journals, including the Transplantation, Transplant Immunology, and Annals of Surgery, and is co-editor-in-chief of Transplantation Reviews. Dr. Knechtle’s research focuses on immunology and transplantation tolerance. He is a founder of Renovar, Inc., a biotechnology company specializing in the field of immunology and transplantation.

Recent Publications (2007 – 2008)

  • Morris PJ and Knechtle SJ (Eds.): Kidney Transplantation: Principles and Practice, 6th Edition. Philadelphia: Saunders Elsevier, 2008.  
  • Odorico JS, Sollinger HW, Knechtle SJ: Pancreas transplantation: the University of Wisconsin experience. In: Pancreatic Transplantation. RJ Corry and R Shapiro (Eds.). New York, Informa Healthcare, pp. 333-357, 2007.  
  • Schadde E, D’Alessandro AM, Musat AI, Torrealba JR, Knechtle SJ: Donor-specific HLA-antibody-mediated humoral rejection in a liver transplant recipient fully reversed with plasmapheresis and immunoglobulin. In: Clinical Transplants 2006.  
  • PI Terasaki (Ed.). Los Angeles, Terasaki Foundation Laboratory, pp. 479-482, 2007.  
  • Barth RN, Knechtle SJ: New immunosuppressive protocols. In: Living Donor Organ Transplantation. RWGGruessner and E Benedetti (Eds.). New York, McGraw Hill, pp. 731-736, 2008.  
  • Knechtle SJ, Pirsch JD: Early course of the patient with a kidney transplant. In: Kidney Transplantation: Principles and Practice, 6th Edition. PJ Morris and SJ Knechtle (Eds.). Philadelphia, Saunders Elsevier, pp. 210-219, 2008.  
  • Knechtle SJ, Morris P: Results of renal transplantation. In: Kidney Transplantation: Principles and Practice, 6th Edition. PJ Morris and SJ Knechtle (Eds.). Philadelphia, Saunders Elsevier, pp. 657-675, 2008.  
  • Sollinger HW, Becker YT, Burlingham W, D’Alessandro AM, Fernandez LA, Hullett D, Knechtle SJ, Odorico JS, O’Loughlin S, Pirsch JD, Rieselbach RE, Sundberg A, Voss B: The history of the University of Wisconsin Transplant Program. In: Clinical Transplants 2007. JM Cecka and PI Terasaki (Eds.). Los Angeles, Terasaki Foundation Laboratory, pp. 271-287, 2008.  
  • Hanish SI, Knechtle SJ: Alemtuzumab. In: Transplantomecum. J Alberu (Ed.). Barcelona, Permanyer, 2008 (in press)  
  • Xu Q, Lee J, Jankowska-Gan E, Schultz J, Roenneburg DA, Haynes LD, Kusaka S, Sollinger HW, Knechtle SJ, VanBuskirk AM, Torrealba JR, Burlingham WJ: Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 2007; 178:3983-3995.  
  • Dar WA, Knechtle SJ: CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signaling through the T-cell receptor. Immunology 2007; 120:467-485.  
  • Schadde E, Knechtle SJ: Review: chemokines in transplantation. Transplant Rev 2007; 21:107-118.  
  • Pascual J, Mezrich JD, Djamali A, Leverson G, Chin LT, Torrealba J, Bloom D, Voss B, Becker BN, Knechtle SJ, Sollinger HW, Pirsch JD, Samaniego MD: Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation. Transplantation 2007; 83:1429-1434.  
  • D’Alessandro AM, Knechtle SJ, Chin LT, Fernandez LA, Yagci G, Leverson G, Kalayoglu M: Liver transplantation in pediatric patients: Twenty years of experience at the University of Wisconsin. Pediatr Transplant 2007; 11:661-670.Bonatti H, Nguyen JH, Knechtle SJ, Pruett TL: Liver transplantation 2007: where do we go from here? Curr Opin Organ Transplant 2007; 12:211-214.  
  • Kirk AD, Cherikh WS, Ring M, Burke G, Kaufman D, Knechtle SJ, Potdar S, Shapiro R, Dharnidharka VR, Kauffman HM: Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab. Am J Transplant 2007; 7:2619-2625.  
  • Molitor-Dart ML, Andrassy J, Kwun J, Kayaoglu HA, Roenneburg DA, Haynes LD, Torrealba JR, Bobadilla JL, Sollinger HW, Knechtle SJ, Burlingham WJ: Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. J Immunol 2007; 179:6749-6761.  
  • Kwun J, Hu H, Schadde E, Roenneburg D, Sullivan KA, DeMartino J, Burlingham WJ, Knechtle SJ: Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. J Immunol 2007; 179:8016-8025.  
  • Brem-Exner BG, Sattler C, Hutchinson JA, Koehl GE, Kronenberg K, Farkas S, Inoue S, Blank C, Knechtle SJ, Schlitt HJ, Fandrich F, Geissler EK: Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J.Immunol 2008; 180:335-349.  
  • Bloom DD, Chang Z, Fechner JH, Dar W, Polster SP, Pascual J, Turka LA, Knechtle SJ: CD4+CD25+FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant 2008; 8:793-802.Gingles B, Knechtle S: Surgical invention and commercialization. Surgery 2008; 143:175-181.  
  • Yagci G, Fernandez LA, Knechtle SJ, D’Alessandro AM, Chin LT, Musat AI, Lucey MR, Said A, PirschJD, Leverson G, Kalayoglu M: The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C. Transplant Proc 2008; 40:219-223.  
  • Haustein SV, Kolterman AJ, Sundblad JJ, Fechner JH, Knechtle SJ: Nonhuman primate infections after organ transplantation. ILAR J 2008; 49:209-219.  
  • Pascual J, Samaniego MD, Torrealba JR, Odorico JS, Djamali A, Becker YT, Voss B, Leverson GE, KnechtleSJ, Sollinger HW, Pirsch JD: Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol 2008; 19:812-824.  
  • Pescovitz MD, Knechtle S, Alexander SR, Colombani P, Nevins T, Nieforth K, Bouw MR: Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients. Pediatr Transplant 2008; 12:447-455.  
  • Pascual J, Bloom D, Torrealba J, Brahmbhatt R, Chang Z, Sollinger HW, Knechtle SJ: Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T regulatory cells. Am J Transplant 2008; 8:1529-1536.  
  • Schadde E, D’Alessandro AM, Knechtle SJ, Odorico JS, Becker YT, Pirsch JD, Sollinger HW, Fernandez LA: Alemtuzumab induction and triple maintenance immunotherapy in kidney transplantation from donors after cardiac death. Transpl Int 2008; 21:625-636.  
  • Spier BJ, Pfau PR, Lorenze KR, Knechtle SJ, Said A: Risk factors and outcomes in post-liver transplantation bile duct stones and casts: a case control study. Liver Transpl 2008 (in press).  
  • Kwun J, Hazinedaroglu SM, Schadde E, Kayaoglu HA, Fechner J, Hu H, Roenneburg D, Torrealba J, Shiao L, Hong X, Peng R, Szewczyk JW, Sullivan KA, DeMartino J, Knechtle SJ: Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. Am J Transplant 2008 (in press).  
  • Pascual J, Pirsch JD, Odorico JS, Torrealba JR, Djamali A, Becker YT, Voss B, Leverson GE, Knechtle SJ, Sollinger HW, Samaniego MD: Alemtuzumab induction and antibody-mediated kidney rejection after simultaneous pancreas-kidney transplantation. Transplantation, 2008 (in press).