Thomas C. Pearson, MD, D Phil - Basic Science Research Faculty

Thomas C. Pearson, MD, D Phil

Executive Director, Emory Transplant Center
Surgical Director, Kidney Transplantation
Livingston Professor of Surgery, Division of Transplantation, Department of Surgery

T cells play a central and critical role in the rejection of transplanted organs. Dr. Pearson’s research has focused on better understanding the critical factors for T cell activation and function and the development of novel strategies to block the rejection response. These investigations have involved the development and assessment of novel immunomygelatory strategies in rodent models and pertinent pre-clinical testing in non-human primates.  These investigations, on the whole of the costimulatory pathways and the alloimmune response, have the ultimate goal of developing a clinically relevant strategy to induce permanent long-term tolerance to transplanted organs in humans.

Recent Publications (2007 – 2008)

  • Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.” J Exp Med., Feb 2007, 19: 204 (2): 299-309.  
  • Gangappa,S, Larsen CP, Pearson TC. “Alloimmunity: No Toll Exemption.” AM J. Transplant. Jan. 2007, 7: 3-4.  
  • Ford M, Wagener M, Gangappa S, Pearson TC, Larsen CP. “Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.  Am J Transplant. 2007 Jun: 7(6): 1471-81.  
  • Tomlanovich S.J., Pearson TC, Gallon L. “Evolving Strategies for Immunosuppression in  Renal Transplantation: A Review of Recent Clinical Trials. Johns Hopkins (Adv. Stud. Med.) 2007, 7(9): 275-280.  
  • Koehn, B.H., Williams, M.A., Borom, K., Gangappa, S., Pearson, T.C., Ahmed, R., Larsen C.P.  “Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.  J. Immunol, Aug. 2007, 179(4):2616-26.  
  • Gangappa, S., Kokko, K.E., Carlson, L.M., Gourley, T., Newell, K.A., Pearson, T.C., Ahmed, R., Larsen, C.P. “Immune responsiveness and protective immunity after transplantation”. Transplant International, April 2008, 21(4):293-303.  
  • Rigby, M.R., Trexler, A.M., Pearson, T.C., and Larsen, C.P. CD28/CD154 blockade prevents autoimmune diabetes by inducing non-deletional tolerance following effector T cell expansion. Diabetes, May 2008 (ePub).  
  • Ford, M.L., Wagener, J.E., Hanna, S.S., Pearson, T.C, Kirk, A.D. and Larsen, C.P. A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154–independent rejection. J Immunol, June 2008,180(11).