Emory Transplant Center Publications

Faculty at the Emory Transplant Center (ETC) were involved in 75 publications in 47 different journals in FY11, including publications in all top 10 scientific journals. These top scientific journals included:

• New England Journal of Medicine
• American Journal of Transplantation
• Transplantation
• Journal of Clinical Investigation
• Journal of Experimental Medicine
• Journal of the American College of Cardiology
• Journal of Cardiac Failure
• Annals of Thoracic Surgery
• Journal of the American Society of Nephrology
• Kidney International
• Diabetes Care

Publications from FY11 included:

1. Araki K, Gangappa S, Dillehay DL, Rouse BT, Larsen CP, Ahmed R. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.J Exp Med. 2010 Oct 25;207(11):2355-67. Epub 2010 Oct 4.

2. Atif F, Sayeed I, Yousuf S, Ishrat T, Hua F, Wang J, Brat DJ, Stein DG. Progesterone Inhibits the Growth of Human Neuroblastoma: In Vitro and In Vivo Evidence.Mol Med. 2011 Jun 17. [Epub ahead of print]

3. Bingaman AW, Bray RA, Gebel HM, Newell KA. Paired kidney donation: a (virtual) balancing act.Am J Transplant. 2011 Feb;11(2):194-5. Epub 2011 Jan 10.

4. Bradley JA, Baldwin WM, Bingaman A, Ellenrieder C, Gebel HM, Glotz D, Kirk AD. Antibody-mediated rejection--an ounce of prevention is worth a pound of cure.Am J Transplant. 2011 Jun;11(6):1131-9.

5. Dar W, Agarwal A, Watkins C, Gebel HM, Bray RA, Kokko KE, Pearson TC, Knechtle SJ. Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplants.Am J Transplant. 2011 Apr;11(4):841-7.

6. Ferrer IR, Araki K, Ford ML. Paradoxical aspects of rapamycin immunobiology in transplantation.Am J Transplant. 2011 Apr;11(4):654-9. Review.

7. Floyd TL, Koehn BH, Kitchens WH, Robertson JM, Cheeseman JA, Stempora L, Larsen CP, Ford ML. Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.J Immunol. 2011 Feb 15;186(4):2033-41. Epub 2011 Jan 21.

8. Ford ML, Larsen CP. Transplantation tolerance: memories that haunt us. Sci Transl Med. 2011 Jun 8;3(86):86ps22. Erratum in: Sci Transl Med. 2011 Jun 22;3(88):88er4. Sci Transl Med. 2011 Jun 8;3(86).

9. Hanish SI, Knechtle SJ. Liver transplantation for the treatment of hepatocellular  carcinoma. Oncology (Williston Park). 2011 Jul;25(8):752-7. Review.

10. Hsu HC, Yang P, Wu Q, Wang JH, Job G, Guentert T, Li J, Stockard CR, Le TV, Chaplin DD, Grizzle WE, Mountz JD. Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. Arthritis Rheum. 2011 Jul;63(7):2038-48.

11. Hua F, Wang J, Ishrat T, Wei W, Atif F, Sayeed I, Stein DG. Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone. J Neuroinflammation. 2011 May 8;8:42.

12. Kirk AD, Knechtle SJ, Larsen CP, Newell KA, Pearson TC. Miles to go. Am J Transplant. 2011 Jun;11(6):1119-20.

13. Kirk AD, Feng S. Surgeons and research: talent, training, time, teachers and teams. Am J Transplant. 2011 Feb;11(2):191-3. Epub 2011 Jan 12.

14. Kirk AD, Turgeon NA, Iwakoshi NN. B cells and transplantation tolerance. Nat Rev Nephrol. 2010 Oct;6(10):584-93. Epub 2010 Aug 24. Review.

15. Kirk AD. Now what? Am J Transplant. 2010 Nov;10(11):2385-6.

16. Kitchens WH, Larsen CP, Ford ML. Integrin antagonists for transplant immunosuppression: panacea or peril? Immunotherapy. 2011 Mar;3(3):305-7.

17. Knechtle SJ. Seek and you will find: antibody and the liver. Am J Transplant. 2011 Mar;11(3):424-5.

18. Knechtle SJ. Guidance for liver transplant immunosuppression. Am J Transplant. 2011 May;11(5):886-7. doi: 10.1111/j.1600-6143.2011.03488.x. Epub 2011 Apr 5.

19. Knechtle SJ. Immunoregulation and tolerance. Transplant Proc. 2010 Nov;42(9 Suppl):S13-5. Review.

20. Larsen CP, Griny AJ, Medina-Pestana J, Vanrenterghem Y, Vincenti F, Breshahan B, Campistol JM, Florman S, Rial Mdel C, Kamar N, Block A, Di Russo G, Lin CS, Garg P, Charpentier B. Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies. Transplantation. 2010 Dec 27;90(12):1528-35.

21. Larsen CP, Page A, Linzie KH, Russell M, Deane T, Stempora L, Strobert E, Penedo MC, Ward T, Wiseman R, O'Connor D, Miller W, Sen S, Singh K, Kean LS. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.Am J Transplant. 2010 Nov;10(11):2396-409. Epub 2010 Sep 17.

22. Lo DJ, Weaver TA, Stempora L, Mehta AK, Ford ML, Larsen CP, Kirk AD. Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression. Am J Transplant. 2011 Jan;11(1):22-33. Epub 2010 Nov 10.

23. Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, et al. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010 Dec 9;116(24):5403-18. Epub 2010 Sep 10.

24. Neujahr DC, Mohammed A, Ulukpo O, Force SD, Ramirez AM, Pelaez A, Lawrence EC, Larsen CP, Kirk AD. Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series.Chest. 2010 Oct;138(4):937-43. Epub 2010 Jun 3.

25. Newell KA, Chong AS. Making a B-line for transplantation tolerance. Am J Transplant. 2011 Mar;11(3):420-1.

26. Newell KA. Clinical transplantation tolerance. Semin Immunopathol. 2011 Mar;33(2):91-104. Epub 2011 Feb 14. Review.

27. Saxena NK, Fu PP, Nagalingam A, Wang J, Handy J, Cohen C, Tighiouart M, Sharma D, Anania FA. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma.Gastroenterology. 2010 Nov;139(5):1762-73, 1773.e1-5. Epub 2010 Jul 13.

28. Sharma D, Wang J, Fu PP, Sharma S, Nagalingam A, Mells J, Handy J, Page AJ, Cohen C, Anania FA, Saxena NK. Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.Hepatology. 2010 Nov;52(5):1713-22.

29. Thompson P, Cardona K, Russell M, Badell IR, Shaffer V, Korbutt G, Rayat GR, Cano J, Song M, Jiang W, Strobert E, Rajotte R, Pearson T, Kirk AD, Larsen CP. CD40-specific costimulation blockade enhances neonatal porcine islet survival  in nonhuman primates.Am J Transplant. 2011 May;11(5):947-57.

30. Thompson P, Badell IR, Lowe M, Cano J, Song M, Leopardi F, Avila J, Ruhil R, Strobert E, Korbutt G, Rayat G, Rajotte R, Iwakoshi N, Larsen CP, Kirk AD. Islet Xenotransplantation Using Gal-Deficient Neonatal Donors Improves Engraftment and  Function.Am J Transplant. 2011 Aug 29.

31. Lo DJ, Weaver TA, Kleiner DE, Mannon RB, Jacobson LM, Becker BN, Swanson SJ, Hale DA, Kirk AD. Chemokines and their receptors in human renal allotransplantation.Transplantation. 2011 Jan 15;91(1):70-7.

32. Turgeon NA, Avila JG, Cano JA, Hutchinson JJ, Badell IR, Page AJ, Adams AB, Sears MH, Bowen PH, Kirk AD, Pearson TC, Larsen CP. Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.Am J Transplant. 2010 Sep;10(9):2082-91.

33. Turner AP, Shaffer VO, Araki K, Martens C, Turner PL, Gangappa S, Ford ML, Ahmed R, Kirk AD, Larsen CP. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.Am J Transplant. 2011 Mar;11(3):613-8.

34. Vanrenterghem Y, Bresnahan B, Campistol J, Durrbach A, Grinyó J, Neumayer HH, Lang P, Larsen CP, Mancilla-Urrea E, Pestana JM, Block A, Duan T, Glicklich A, Gujrathi S, Vincenti F. Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies).Transplantation. 2011 May 15;91(9):976-83.PubMed [citation] PMID: 21372756

35. Vezys V, Penaloza-MacMaster P, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.J Immunol. 2011 Aug 15;187(4):1634-42. Epub 2011 Jul 8.

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