Publications

Allan D. Kirk, MD

Selected from over 170 publications

Chari R, Collins BH, Magee JC, Dimaio JM, Kirk AD, Harland RC, McCann RL, Platt JL, Meyers WC. Treatment of hepatic failure with ex-vivo pig liver perfusion followed by liver transplantation. New Engl J Med 331:234-237, 1994.

Kirk AD, Harlan DM, Armstrong NN, Davis TA, Dong Y, Gray GS, Hong X, Thomas D, Fechner JH Jr, Knechtle SJ. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 94:8789-8794, 1997.

Kirk AD, Burkly LC, Batty DS, Baumgartner RE, Berning JD, Buchanan K, Fechner JH, Germond RL, Kampen RL, Patterson NB, Tadaki DK, TenHoor CN, White L, Knechtle SJ, Harlan DM. Humanized anti-CD154 monoclonal antibody treatment prevents acute renal allograft rejection in non-human primates. Nature Medicine 5:686-693, 1999.

Kirk AD, Jacobson LM, Heisey DM, Fass NA, Pirsch JD, Sollinger HW. Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function. Transplantation 68:1578-1582, 1999.

Kirk AD. Transplant Tolerance: a look at the non-human primate literature in the view of modern tolerance theories. Crit Rev Immunol 19:349-88, 1999.

Kirk AD, Tadaki DK, Celniker A, Batty DS, Berning JD, Colonna JO, Cruzata F, Elster EA, Gray GS, Kampen RL, Patterson NB, Szklut P, Swanson J, Xu H, Harlan DM. Induction Therapy with Monoclonal Antibodies Specific for CD80 and CD86 Delays the Onset of Acute Renal Allograft Rejection in Non-human Primates. Transplantation 72:377-84, 2001.

Kirk AD, Blair PJ, Tadaki DK, Xu H, Harlan DM. The role of CD154 in organ transplant rejection and acceptance. Philos Trans R Soc Lond B Biol Sci 356:691-702, 2001.

Kirk AD. Location, location, location: Regional immune mechanisms critically influence rejection. Nat Med 8:553-5, 2002.

Hoffmann SC, Kampen RL, Amur S, Sharaf MA, Kleiner DE, Hunter K, Swanson SJ, Hale DA, Mannon RB, Blair PJ, Kirk AD. Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia/reperfusion injury. Transplantation 74: 916-923, 2002.

Montgomery SP, Xu H, Tadaki DK, Celniker A, Burkly LC, Berning JD, Cruzata F, Elster EA, Gray G, Kampen RL, Swanson SJ, Harlan DM, Kirk AD. Combination Induction Therapy with Monoclonal Antibodies Specific for CD80, CD86 and CD154 in Non-human Primate Renal Transplantation. Transplantation  74:1365-1369, 2002.

Swanson SJ, Hale DA, Mannon RB, Kleiner DE, Chamberlain CE, Polly S, Harlan DM, Kirk AD. Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. The Lancet 360:1662-1664, 2002.

Xu H, Montgomery SP, Preston EH, Tadaki DK, Hale DA, Harlan DM, Kirk AD. Studies investigating pre-transplant donor specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a non-human primate model of skin allotransplantation. J Immunol 170:2776-2782, 2003.

Kirk AD, Hale DA, Mannon RB, Kleiner DE, Hoffmann SC, Kampen RL, Cendales LK, Tadaki DK, Harlan DM, Swanson SJ. Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody Campath-1H. Transplantation 76:120-129, 2003.

Kirk AD. Crossing the Bridge: Large Animal Models in Translational Transplantation Research. Imm Rev 196:176-196, 2003.

Kirk AD. Ethics in the Quest for Transplant Tolerance. Transplantation 77:947-951, 2004.

Czapiga M, Kirk AD, Lekstrom-Himes J. Platelets Deliver Costimulatory Signals to Antigen-Presenting Cells: a Potential Bridge between Injury and Immune Activation. Exp Hematol. 32:135-9, 2004.

Pearl JP, Parris J, Hale DA, Hoffmann SC, Bernstein WB, McCoy KL, Swanson SJ, Mannon RB, Roederer M, Kirk AD. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transplant 5:465-74, 2005.

Hoffmann SC, Hale DA, Kleiner DE,  Mannon RB,  Kampen RL, Jacobson L,  Cendales LC, Swanson SJ, Becker BN, Kirk AD. Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 5:573-81, 2005.

Preston EH, Xu H, Dhanireddy KK, Pearl, JP, Leopardi FV, Starost MF, Hale DA, Kirk AD. Synergy between IDEC-131 (anti-CD154), sirolimus, and donor-specific transfusion facilitates operational tolerance following renal transplantation in non-human primates. Am J Transplant 5:1032-41, 2005.

Czapiga M, Gao J, Kirk AD, Lekstrom-Himes J. Human Platelets Exhibit Chemotaxis using Functional N-formyl Peptide Receptors. Exp Hematol 33:73-84, 2005.

Kirk AD, Mannon RB, Kleiner DE, Swanson SJ, Kampen RL, Cendales LK, Elster EA, Wakefield T, Chamberlain C, Hoffmann SC, Hale DA. Results from a Human Renal Allograft Tolerance Trial Evaluating T-Cell Depletion with Alemtuzumab combined with Deoxyspergualin. Transplantation 80:1051-9, 2005.

Xu H, Dhanireddy KK, Kirk AD. Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T-cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. J Immunol 176: 750–761, 2006.

Xu H, Zhang X, Mannon RB, Kirk AD. Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell bound CD154. J Clin Invest 116: 769-774, 2006.

Newell KA, Larsen CP, Kirk AD. Transplantation Tolerance: Converging on a moving target. Transplantation 81:1-6, 2006.

Kirk AD. Meteorology and Tolerance. Am J Transplant 6:645-646, 2006.

Kirk AD, Hale DA, Ford E, Kleiner DE, Kampen RL, Elster EA, Swanson SJ, Cendales L, Cropper T, Hale L, Jordan S, Koussis T, Peretti J, Sloane A, Salaita C, Ring M, Chamberlain C, Mannon RB. Solid Organ Transplantation at the National Institutes of Health: Development of a Research Based Transplantation Practice. in Clinical Transplants 2005. Cecka and Terasaki (Eds), UCLA Tissue Typing Laboratory, Los 131-144, 2006.

Kirk AD, Light JA. Of Ends and Means. Am J Transplant 6: 2228-9, 2006.

Kirk AD. Overview: Induction Immunosuppression. Transplantation 82: 503-602, 2006.

Kirk AD, Cherikh WS, Ring R, Burke G, Kaufman D, Knechtle SJ, Potdar S, Shapiro R, Dharnidharka VR, Kauffman HM. Dissociation of Depletional Induction and Post Transplant Lymphoproliferative Disease in Kidney Recipients Treated With Alemtuzumab. Am J Transplant. 7:2619-25, 2007.

Girlanda R, Kleiner DE, Duan Z, Ford EAS, Wright EC, Mannon RB, Kirk AD. Monocyte infiltration and kidney allograft dysfunction during acute rejection. Am J Transplant. 8:600-607, 2008.

Dhanireddy KK, Bruno DA, Weaver TA, Xu H, Zhang X, Leopardi FV, Hale DA, Kirk AD. Portal Venous Donor Specific Transfusion in Conjunction with Sirolimus Prolongs Renal Allograft Survival in Non-Human Primates. Am J Transplant. 2008.

Christian P. Larsen, MD, DPhil

Garber, D.A., G. Silvestri, A.P. Barry, A. Fedanov, N. Kozyr, H. McClure, D.C. Montefiori, C.P. Larsen, J.D. Altman, S.I. Staprans, and M.B. Feinberg. 2004. Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication. The Journal of Clinical Investigation 113:836-845.

Nanji, S.A., W.W. Hancock, C.C. Anderson, A.B. Adams, B. Luo, C.D. Schur, R.L. Pawlick, L. Wang, A.J. Coyle, C.P. Larsen, and A.M. Shapiro. 2004. Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. Am J Transplant 4:526-536.

Shirasugi, N., N. Emmanouilidis, T.C. Pearson, and C.P. Larsen. 2004. Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance. Transplantation proceedings 36:2423-2424.

Adams, A.B., N. Shirasugi, T.R. Jones, M.M. Durham, E.A. Strobert, S. Cowan, P. Rees, R. Hendrix, K. Price, N.S. Kenyon, D. Hagerty, R. Townsend, D. Hollenbaugh, T.C. Pearson, and C.P. Larsen. 2005. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 174:542-550.

Dai, Z., I.W. Nasr, M. Reel, S. Deng, L. Diggs, C.P. Larsen, D.M. Rothstein, and F.G. Lakkis. 2005. Impaired recall of CD8 memory T cells in immunologically privileged tissue. J Immunol 174:1165-1170.

Emmanouilidis, N., and C.P. Larsen. 2005. Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice. Methods in molecular medicine 109:459-468.

Kemball, C.C., E.D. Lee, V. Vezys, T.C. Pearson, C.P. Larsen, and A.E. Lukacher. 2005. Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection. J Immunol 174:7950-7960.

Larsen, C.P., T.C. Pearson, A.B. Adams, P. Tso, N. Shirasugi, E. Strobertm, D. Anderson, S. Cowan, K. Price, J. Naemura, J. Emswiler, J. Greene, L.A. Turk, J. Bajorath, R. Townsend, D. Hagerty, P.S. Linsley, and R.J. Peach. 2005. Rational development of LEA29Y (Belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 5:443-453.

Vincenti, F., C. Larsen, A. Durrbach, T. Wekerle, B. Nashan, G. Blancho, P. Lang, J. Grinyo, P.F. Halloran, K. Solez, D. Hagerty, E. Levy, W. Zhou, K. Natarajan, and B. Charpentier. 2005. Costimulation blockade with Belatacept in renal transplantation. The New England Journal of Medicine 353:770-781. * Co-first and corresponding author
Cardona, K., G.S. Korbutt, Z. Milas, J. Lyon, J. Cano, W. Jiang, H. Bello-Laborn, B. Hacquoil, E. Strobert, S. Gangappa, C.J. Weber, T.C. Pearson, R.V. Rajotte, and C.P. Larsen. 2006. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nature Medicine 12:304-306.

Emmanouilidis, N., Z. Guo, Y. Dong, M. Newton-West, A.B. Adams, E.D. Lee, J. Wang, T.C. Pearson, C.P. Larsen, and K.A. Newell. 2006. Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells. Transplantation 81:455-462.

Han Lee, E.D., C.C. Kemball, J. Wang, Y. Dong, D.C. Stapler, Jr., K.M. Hamby, S. Gangappa, K.A. Newell, T.C. Pearson, A.E. Lukacher, and C.P. Larsen. 2006. A mouse model for polyomavirus-associated nephropathy of kidney transplants. Am J Transplant 6:913-922.

Kean, L.S., S. Gangappa, T.C. Pearson, and C.P. Larsen. 2006. Transplant tolerance in non-human primates: progress, current challenges and unmet needs. Am J Transplant 6:884-893.

Kean, L.S., K. Hamby, B. Koehn, E. Lee, S. Coley, L. Stempora, A.B. Adams, E. Heiss, T.C. Pearson, and C.P. Larsen. 2006. NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation. Am J Transplant 6:292-304.

Kemball, C.C., E.D. Lee, E. Szomolanyi-Tsuda, T.C. Pearson, C.P. Larsen, and A.E. Lukacher. 2006. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol 176:1814-1824.

Koehn, B., S. Gangappa, J.D. Miller, R. Ahmed, and C.P. Larsen. 2006. Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation. J Immunol 176:2691-2696.

Larsen, C.P., S.J. Knechtle, A. Adams, T. Pearson, and A.D. Kirk. 2006. A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. Am J Transplant 6:876-883.

Bray, R.A., D.L. Nolen, C. Larsen, T. Pearson, K.A. Newell, K. Kokko, A. Guasch, P. Tso, J.B. Mendel, and H.M. Gebel. 2006. Transplanting the highly sensitized patient: the Emory algorithm. Am J Transplant 6:2307-2315.

 Li, J.M., J. Gorechlad, C.P. Larsen, and E.K. Waller. 2006. Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 12:1239-1249.

Newell, K.A., and C.P. Larsen. 2006. Toward transplantation tolerance: a large step on a long road. Am J Transplant 6:1989-1990.

Newell, K.A., and C.P. Larsen. 2006. Tolerance assays: measuring the unknown. Transplantation 81:1503-1509.

Newell, K.A., C.P. Larsen, and A.D. Kirk. 2006. Transplant tolerance: converging on a moving target. Transplantation 81:1-6.

Vezys, V., D. Masopust, C.C. Kemball, D.L. Barber, L.A. O'Mara, C.P. Larsen, T.C. Pearson, R. Ahmed, and A.E. Lukacher. 2006. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. The Journal of experimental medicine 203:2263-2269.

Cardona, K., Z. Milas, E. Strobert, J. Cano, W. Jiang, S.A. Safley, S. Gangappa, B.J. Hering, C.J. Weber, T.C. Pearson, and C.P. Larsen. 2007. Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. Am J Transplant 7:2260-2268.

Ford, M.L., B.H. Koehn, M.E. Wagener, W. Jiang, S. Gangappa, T.C. Pearson, and C.P. Larsen. 2007. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. The Journal of experimental medicine 204:299-309.

Ford, M.L., M.E. Wagener, S. Gangappa, T.C. Pearson, and C.P. Larsen. 2007. Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models. Am J Transplant 7:1471-1481.

Gangappa, S., C.P. Larsen, and T.C. Pearson. 2007. Alloimmunity: no toll exemption. Am J Transplant 7:3-4.

Hamby, K., A. Trexler, T.C. Pearson, C.P. Larsen, M.R. Rigby, and L.S. Kean. 2007. NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism. Am J Transplant 7:1884-1896.

Kean, L.S., A.B. Adams, E. Strobert, R. Hendrix, S. Gangappa, T.R. Jones, N. Shirasugi, M.R. Rigby, K. Hamby, J. Jiang, H. Bello, D. Anderson, K. Cardona, M.M. Durham, T.C. Pearson, and C.P. Larsen. 2007. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. Am J Transplant 7:320-335.

Koehn, B.H., M.A. Williams, K. Borom, S. Gangappa, T.C. Pearson, R. Ahmed, and C.P. Larsen. 2007. Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. J Immunol 179:2616-2626.

Mueller, S.N., M. Matloubian, D.M. Clemens, A.H. Sharpe, G.J. Freeman, S. Gangappa, C.P. Larsen, and R. Ahmed. 2007. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proceedings of the National Academy of Sciences of the United States of America 104:15430-15435.

Newell, K.A., and C.P. Larsen. 2007. Transplantation tolerance. Seminars in nephrology 27:487-497.

Singh, N., P.R. Chandler, Y. Seki, B. Baban, M. Takezaki, D.J. Kahler, D.H. Munn, C.P. Larsen, A.L. Mellor, and M. Iwashima. 2007. Role of CD28 in fatal autoimmune disorder in scurfy mice. Blood 110:1199-1206.

Zahorchak, A.F., L.S. Kean, D. Tokita, H.R. Turnquist, M. Abe, J. Finke, K. Hamby, M.R. Rigby, C.P. Larsen, and A.W. Thomson. 2007. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation 84:196-206.

 Emamaulee, J.A., S. Merani, C.P. Larsen, and A.M. Shapiro. 2008. Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity. Transplantation  Jan 15:118-124.

Gangappa, S., and C.P. Larsen. 2008. Immunosuppressive protocols for pig-to-human islet transplantation; lessons from pre-clinical non-human primate models. Xenotransplantation Mar 15:107-111.

Dobbels, F., P. Moons, I. Abraham, C.P. Larsen, L. Dupont, S. De Geest. 2008. Measuring system experience of side-effects of immunosuppressive drugs; the modified transplant symptom occurrence and distress scale. Transplant Int 21:764-773. Accepted: 3/13/08.

Ford, M.L., M.E. Wagener, S.S. Hanna, T.C. Pearson, A.D. Kirk, and C.P. Larsen. 2008. A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154–independent rejection. J Immunol 180:7203-7211. Accepted 3/24/08.

Gangappa, S., K.E. Kokko, L.M. Carlson, T. Gourley, K.A. Newell, T.C. Pearson, R. Ahmed, and C.P. Larsen. 2008. Immune responsiveness and protective immunity after transplantation. Transplant Int 21:293-303. Accepted: 12/20/07.

Rigby, M.R., A.M. Trexler, T.C. Pearson, and C.P. Larsen. 2008. CD28/CD154 blockade prevents autoimmune diabetes by inducing non-deletional tolerance following effector T cell expansion. Diabetes 57:2672-2683. PMCID: PMC2551677.

Kenneth Newell, MD

Wang, J., Guo, Z., Dong, Y., Kim, O., Hart, J., Adams, A., Larsen, C.P., Mittler, R.S., and Newell, K.A.  The Role of 4-1BB in Allograft Rejection Mediated by CD8+ T Cells.  Am. J. Transplant. 3:543-551, 2003.

Guo, Z., Wang, J., Dong, Y., Adams, A.B., Sirasugi, N., Kim, O., Hart, J., Newton-West, M., Pearson, T.C., Larsen, C.P., and Newell, K.A.  Long-term Survival of Intestinal Allografts Induced by Costimulation Blockade, Busulfan, and Donor Bone Marrow Infusion.  Am. J. Transplant. 3:1091-1098, 2003.

Tso, P.L., Cash, M.P., Pearson, T.C., Larsen, C.P., and Newell, K.A.  An Alternative Technique for Simultaneous Pancreas-Kidney Transplantation Utilizing a Common Arterial Conduit: Early Experience and Potential Applications.  Am. J. Transplant. 3:1440-1443, 2003.

Newell, K.A., Larsen, C.P, and Kirk, A.D.  Transplantation Tolernace:  Converging on a Moving Target.  Transplantation 81:1-6, 2006.

Emmanouilidis, N., Guo, Z., Dong, Y., Newton-West, M., Adams, A.B., Han Lee, E.D., Wang, J., Pearson, T.C., Larsen, C.P., and Newell, K.A.  Immunosuppressive and Trafficking Properties of Donor Splenic and Bone Marrow Dendritic Cells.  Transplantation 81(3):455-462, 2006.

Namasivayan, S., Small, W.C., Kalra, M.K., Torres, W.E., Newell, K.A., and Mittal, P.K.  Multi-detector Row CT Angiography for Preoperative Evlauation of Potential Laparoscopic Renal Donors:  How Accurate Are We?  Clinical Imaging.  30(2):120-126, 2006.

Newell, K.A. and Larsen, C.P.  Tolerance Assays:  Measuring the Unknown.  Transplantation 81(11):1503-1509, 2006.

Han Lee, E.D.,  Kemball, C.C.,  Wang, J., Dong, Y., Stapler, D.C., Jr., Hamby, K.M.,  Newell, K.A., Pearson, T.C., Lukacher, A.E.,  and Larsen, C.P.  A Mouse Model for Polyomavirus-Associated Nephropathy of Kidney Transplants.  Am. J. Transplant.  6(5):913-922, 2006.

Green, M., Michaels, M.G., Katz, B.Z., Burroughs, M., Gerber, D., Shneider, B.L., Newell, K., Rowe, D., Hultquist, M., and Reyes, J.  CMV-IVIG for Prevention of Epstein Barr Virus Disease and Post Transplant Lymphoproliferative Disease in Pediatric Liver Transplant Recipients.  Am J Transplant. 6:1906-1912, 2006.

Bray, R.A., Nolen, J.D.L., Larsen, C., Pearson, T., Newell, K.A., Kokko, K., Guasch, A., Tso, P., Mendel, J.B., and Gebel, H.M.  Transplanting the Highly Sensitized Patient.  Am. J. Transplant. 6:2307-2315, 2006.

Newell, K.A. and C.P. Larsen.  Toward Transplantation Tolerance:  A Large Step on a Long Road.  Am. J. Transplant. 6:1989-90, 2006.

Najafian, N. and Newell, K.A.  How Can We Measure Immunologic Tolerance in Humans?  J. Am. Soc. Neph. 17(10):2652-2663, 2006.

Wang, J., Dong, Y., Sun, J-Z., Taylor, R.T., Guo, C., Alegre, M-L., Williams, I.R., and Newell, K.A.  Donor Lymphoid Organs Are a Major Site of Alloreactive T Cell Priming Folllowing Intestinal Transplantation.  Am. J. Transplant. 6(11):2563-2571, 2006.

Newell, K.A. and C.P. Larsen.  Transplantation Tolerance.  Sem. Nephrol. 27:487-497, 2007.

Newell, K.A., Cendales, L.C., and A.D. Kirk.  Finding the Right Job for the Tool:  Alembuzumab and Its Role in Renal Transplantation.  Am. J. Transplant. (in press).

Thomas Pearson, MD

Shirasugi N, Emmanouilidis N, Pearson TC, Larsen CP. “Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.” Transplant Proc 2004, Oct;36(8):2423-4.

Adams AB, Shirasugi N, Jones TR, Durham MM, Strobert EA, Cowan S, Rees P, Hendrix R, Price K. Kenyon NS, Hagerty D, Townsend R, Hollengaugh D, Pearson TC, Larsen CP. “Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.” J Immunol 2005, Jan1;174(1):542-50.

Vincenti F, Mendez R, Curtis J, Light J, Pearson T, Wu YM, Katz SM, Akalin E, Ester R, GugliuzzaK, Shihab F, Jordan S, Jonsson J, Molmenti E, Barbeito R. “A multicenter, prospective study of C2-monitored Neoral® in a U.S. population of de novo renal transplant recipients.” Transplantation 2005.

Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobertm E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Truk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ. “Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.” Am J Transplant 2005 Mar; 5 (3):443-53.

Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Lukacher AE. “Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.” J Immunol 2005 Jun 15;174 (12):7950-60.

Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP. “NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.” Am J Transplant 2006 Feb;6(2):292-304.

Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE. “Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection.” J Immunol. 2006 Feb 1; 176(3): 181-24.

Emmanouilidis N, Guo A, Dong Y, Newton-West M, Adams A, Lee E, Wang J, Pearson TC, Larsen CP, Newell KA. “Immunosuppressive and Trafficking Properties of Donor Splenic and Bone Marrow Dendritic Cells.” Transplantation 2006;81:455-462.

Cardona K, Korbutt GS, Zvonimir M, Lyon J, Cano J, Joang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangapa S, Weber J, Pearson TC, Rajotte R, Larsen CP. :Long term survival of neonatal porcine islets in honhuman primates by targeting costimulation pathways.” Nat. Med. 2006 Mar, 12 (3):304-6. Epub 2006 Feb 26.

Larsen CP, Knechtle SJ, Adams A, Pearson TC, Kirk AD. “A New look at Blockade of T-cell Costimulation: A Therapeutic Strategy for Long-germ maintenance immunosuppression.” Am J Transplant. 2006 May;6(5):876-83.

Kean LS, Gangappa S, Pearson TC, Larsen CP. “Transplant tolerance in non-human primates: progress, current challenges and unmet needs.” Am J Transplant 2006 May;6(5):884-93

Han Lee ED, Kemball CC, Wang J, Dong Y, Stapler DC Jr., Hamby KM, Gangappa S, Newell KA, Pearson TC, Lukacher AE, Larsen CP. “A mouse model for polyomavirus-associated nephropathy of kidney transplants. Am J. Transplant. 2006 May’6(5);913-22.

Marks WH, Wagner D, Pearson TC, Orlowski JP, Nelson PW, McGowan JJ, Guidinger MK, Burdick J. “Organ donation and utilization, 1995-2004: entering the collaborative era.” Am J Transplant. 2006; 6 (5 Pt 2): 1101-10.

Bray RA, Nolen JDL, Larsen C, Pearson T, Newell KA, Kokko K, Guasch A, Tso P, Mendel J, Gebel HM. “Transplanting the highly sensitized patient: The Emory algorithm.” Am J Transplant. 2006 6:2307-2315.

Vezys V, Masopust D, Kemball CC, Barber DL, O’mara LA, Larsen CP, Pearson TC, Ahmed R, Lukacher AE. “Continuous recruitment of naïve T cells contributes to heterogeneity of antiviral CD* T cells during persistent infection.” J Exp Med. 2006 Sep 11;[Epub ahead of print

Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.” The Journal of Experimental Medicine. In press 2007.

Gangappa,S, Larsen CP, Pearson TC. “Alloimmunity: No Toll Exemption.” American Journal of Transplantation. 2007: 7:3-4.

Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen, CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. The Journal of Experimental Medicine. Vol. 204, No. 2, Feb. 2007:299-309.

Ford M, Wagener M, Gangappa S, Pearson TC, Larsen CP. “Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models. Am J Tranplant. 2007 Jun;7(6):1471-81.

Paul L. Tso, MD

Tso PL, Bringaze W, Dauterive A, Cohn I et al.  “Gastric carcinoma in the young.”    Cancer, 59(7):1362-5, 1987.

Tso PL, Rodriguez A, Cooper C, Mirvis S et al.  “Sonography in blunt abdominal trauma: a preliminary progress report.”  Journal of Trauma, 33(1):39-44, 1992.

Bumgardner, GL, Wilson GA, Tso PL, Henry ML, Elkhammas EA, Davies EA, Qui W, Ferguson RM.  “Impact of serum lipids on long-term graft and patient survival after renal transplantation.”  Transplantation, 60(12):1418-1421, 1995.

Bumgardner GL, Henry ML, Elkhammas EA, Wilson GA, Tso PL, Davies EA, Qui W, Ferguson RM.  “Obesity as a risk factor after combined pancreas/kidney transplantation.”  Transplantation, 60(12):1426-1430, 1995.

Tso PL, Elkhammas EA, Henry ML, Kim SI, Davies EA, Bumgardner GL, Ferguson    RM.  “Risk factors of long-term survivals in combined kidney/pancreas transplantation.  A multivariate analysis of 259 recipients.”  Transplantation Proceedings, 27(6):3104, 1995.

Tso PL, Cash MP, Pearson TC, Larsen CP, Newell KA. “Simultaneous pancreas-kidney transplantation utilizing a common arterial conduit: early experience and potential applications.” American Journal of Transplantation, 3: 1440-1443, 2003.

Larsen CP, Pearson TC, Adams AB, Tso PL et al.  Rational development of  LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.” American Journal of Transplantation, 5: 443-453, 2005.

Bray RA, Nolen JDL, Larsen CP, Pearson TC, Newell KA, Kokko KE, Guasch A, Tso PL, Mendel JB, Gebel HM.  “Transplanting the highly sensitized patient: the Emory algorithm.” American Journal of Transplantation, accepted for publication July 5, 2006.

Nicole Turgeon, MD

Turgeon NA, Kirk AD, Iwakoshi NN,  Differential Effects of Donor Specific Alloantibody, Transplantation Reviews.  2008.
Fernandez LF*, Turgeon NA*, Odorico JS, Leverson G, Pirsch JD, Becker BN, Becker YT, Knechtle SJ, Foley DP, Shames BD, Kalayoglu M, D’Alessandro AM, Sollinger HW, Superior long term results of simultaneous pancreas-kidney transplantation(SPK) from pediatric donors, American Journal of Transplantation. 2004 Dec; 4(12): 2093-101.

Turgeon NA, Sollinger HW, Fernandez LA, Musat AI, Chin LT, Kalayoglu M, Knechtle SJ, D’Alessandro AM, Hepatic steatosis and liver transplantation, Current Opinion in Organ Transplantation. 2004,9:123-129.

D’Alessandro AM, Fernandez LF, Chin LT, Shames BD, Turgeon NA, Scott DL, DiCarlo A, Becker YT, Odorico JS, Knechtle SJ, Love RB, Pirsch JD, Becker BN, Musat AI, Kalayoglu M, Sollinger HW, Donation after cardiac death: the University of Wisconsin experience, Annals of Transplantation. 2004, Vol. 9, No.1, 2004, pp. 68-71.

Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP, Rossini AA, Appel MC, Alloimmune Injury and Rejection of Human Skin Grafts on HU-PBL-NOD-scid B2mnullMice, Exp Biol Med. 2003 Oct;228(9):1096-104.

Camirand G, Caron NJ, Turgeon NA, Rossini AA, Tremblay JP, Treatment With Anti-CD154 Antibody and Donor-Specific Transfusion Prevents Acute Rejection of Myoblast Transplantation, Transplantation. 2002 Feb 15; 73(3): 453-61.

Iwakoshi NN, Markees TG, Turgeon NA, Thornley T, Cuthbert A, Lief J, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Skin Allograft Maintenance in a New Synchimeric Model System of Tolerance, Journal of Immunology. 2001 Dec 1; 167(11): 6623-30.

Banuelos SJ, Turgeon NA, Shultz LD, Harland RC, Lyons B, Rosini AA, Greiner DL, Appel MC, Human Lymphocyte Reconstituted NOD-scid B2mnullMice Reject Human DR4 Transgenic NOD-scid Mouse Skin, Surgical Forum Volume 2001; Volume N.

Turgeon NA, Iwakoshi NN, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA, Virus Infection Abrogates CD8+ T Cell Deletion Induced by Costimulation Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody, Current Surgery. 2000 Sep 1; 57(5): 505-506.

Turgeon NA, Iwakoshi NN, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA, Virus Infection Abrogates CD8+ T Cell Deletion Induced by Costimulation Blockade, Journal of Surgical Research. 2000 Sep; 93(1):63-9.

Turgeon NA, Iwakoshi NN, Meyers WC, Dahl DM, Shultz LD, Greiner DL, Rossini AA, Human Skin Allograft Rejection in a Small Animal Model, Surgical Forum Volume 2000; Volume M.

Turgeon NA, Iwakoshi NN, Meyers WC, Shultz LD, Greiner DL, Mordes JP, Rossini AA, Analysis of Human Immune Responses to Human Allografts in Small Animal Models, Surgical Forum Volume 1999; Volume L: 393-395.