Research Publications

Christian P. Larsen

Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wang L, Colyle AJ, Larsen CP, Shapiro AM. “Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival.: Am J Transplant 2004; Apr; 4(4):526-36.

Garber DA, Silvestri G, Barry AP, Fedanov A, Kozyr N, McClure H, Montefiori DC, Larsen CP, Altman JD, Staprahs SI, Feinberg MB. “Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication.” J Clin Invest 2004, Mar; 113(6):836-45.

Shirasugi N, Emmanouilidis N, Pearson TC, Larsen CP. “Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.” Transplant Proc 2004, Oct; 36(8):2423-4.

Emmanouilidis N, Larsen CP. “Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice.” Methods Mol Med 2005; 109:459-68.

Adams AB, Shirasugi N, Jones TR, Durham MM, Strobert EA, Cowan S, Rees P, Hendrix R, Price K. Kenyon NS, Hagerty D, Townsend R, Hollengaugh D, Pearson TC, Larsen CP. “Development of a chimeric anti-Cd40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.” J Immunol 2005, Jan1;174(1):542-50.

Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG. “Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue.” J Immunol 2005, Feb 1; 174(3):1165-1170.

Larsen CP, Pearson TC, Adams AB, TSO P, Shirasugi N, Strobertm E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Truk LA, Bajorath J. “Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.” Am J Transplant 2005 Mar; 5 (3) :443-53.

Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Likacher AE. “Late Priming and variability of epitope-specific CD8+ T cell responses during a persistant Virus infection.” J Immunol 2005, June 16; 74 (12): 7950-60.

Vincenti F, Larsen CP, Durrbach A, Wekerle T, Nashan B, Blancho G, Lang P, Grinyo J, Halloran PF, Solez K, Hagerty D Levy E, Zhou W, Natatajan K, Charpentier B; Belatecept Study Group. “Costimulation Blockade with belatacept in renal transplantation.” N Engl J Med 2005, Aug25;353 (8) :770-81.

Newell KA, Larsen CP, Kirk AD. “Transplant tolerance: converging on a moving target.” Transplantation. 2006 Jan 15;81(1): 1-6.

Emmanouilidis N, Guo Z, Dong Y, Newton-West M, Adams A, Lee E, Wang J, Pearson TC. Larsen CP, Newell KA. “Immunosuppressive and Trafficking Properties of Donor Splenic and Bone Marrow Dendric Cells.” Transplantation Feb. 2006;81: 455-462.

Kemball C, Lee E, Szomolany-Tsuda E, Pearson T, Larsen CP, Lukacher A. “Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection.” J Immunol 2006, 176:1814-1824.

Koehn B., Gangappa S., Miller JD, Ahmed R, Larsen CP. “Patients, pathogens and protective immunity: The relevance of virus-induced alloreactivity in transplantation”. J. Immunol. 2006, Mar 1l176(5):2691-6.

Cardona K, Korbutt GS, Zvonimir M, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber J, Pearson T, Rajotte R, Larsen CP. “Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.” Nat. Med. 2006 Mar;12 (3):304-6. Epub 2006 Feb 26.

Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD. “A New look at Blockade of T-cell Costimulation: A Therapeutic Strategy for Long-germ maintenance immunosuppression.” Am J Transplant. 2006 May;6 (5):876-83.

Kean LS, Gangappa S, Pearson TC, Larsen CP. “Transplant tolerance in non-human primates: progress, current challenges and unmet needs.” Am J Transplant 2006 May;6 (5):884-93.

Han Lee ED, Kemball CC, Wang J, Dong Y, Stapler DC Jr., Hamby KM, Gangappa S, Newell KA, Pearson TC, Lukacher AE, Larsen CP. “A mouse model for polyomavirus-associated nephropathy of kidney transplants. Am J. Transplant. 2006 May’6(5);913-22.

Newell KA, Larsen CP. “Toward Transplantation Tolerance: A Large Step on a Long Road.” Am J Transplant. 2006 June 9.

Newell KA, Larsen CP. “Tolerance assays: Measuring the unknown”. Transplantation. 2006 June 15;81(11) 1503-9.

Kean L, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams A, Heiss E, Pearson T, Larsen C. “NK Cells Mediate Costimulation Blockade-Resistant Rejection of Allogeneic Stem Cells During Nonmyeloablative Transplantation.” Am J Transplant. 2006;6 292-304.

Bray RA, Nolen JDL, Larsen CP, Pearson T, Newell K, Kokko K, Guasch A, Tso P, Mendel JB, Gebel, HM. “Transplanting the highly sensitized patient: The Emory algorithm. Am J Transplant. 2006, 6:2307-2315.

Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.” The Journal of Experimental Medicine. In press 2007.

Gangappa S, Larsen CP, Pearson TC. “Alloimmunity: No Toll Exemption.” Am J Transplant. 2007, 7:3-4.

Singh N, Chandler PR, Seki Y, Baban B, Takezaki M, Khaler DJ, Munn DH, Larsen CP, Mellor AL, Iwashima M. “Role of CD28 in Fatal Autoimmune Disorder in Scurfy Mice.” Blood. 2007 April 26.

Ford M, Wagener ME, Gangappa S, Pearson TC, Larsen CP. “Antigenic Disparity Impacts Outcome of Agonism but not Blockade of Costimulatory Pathways in Experimental Transplant Models.” Am J Transplant. 2007 Jun:7(6): 1471-81.

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    • Thomas Pearson

      Shirasugi N, Emmanouilidis N, Pearson TC, Larsen CP. “Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.” Transplant Proc 2004, Oct;36(8):2423-4.

      Adams AB, Shirasugi N, Jones TR, Durham MM, Strobert EA, Cowan S, Rees P, Hendrix R, Price K. Kenyon NS, Hagerty D, Townsend R, Hollengaugh D, Pearson TC, Larsen CP. “Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.” J Immunol 2005, Jan1;174(1):542-50.

      Vincenti F, Mendez R, Curtis J, Light J, Pearson T, Wu YM, Katz SM, Akalin E, Ester R, GugliuzzaK, Shihab F, Jordan S, Jonsson J, Molmenti E, Barbeito R. “A multicenter, prospective study of C2-monitored Neoral® in a U.S. population of de novo renal transplant recipients.” Transplantation 2005.

      Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobertm E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Truk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ. “Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.” Am J Transplant 2005 Mar; 5 (3):443-53.

      Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Lukacher AE. “Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.” J Immunol 2005 Jun 15;174 (12):7950-60.

      Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP. “NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.” Am J Transplant 2006 Feb;6(2):292-304.

      Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE. “Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection.” J Immunol. 2006 Feb 1; 176(3): 181-24.

      Emmanouilidis N, Guo A, Dong Y, Newton-West M, Adams A, Lee E, Wang J, Pearson TC, Larsen CP, Newell KA. “Immunosuppressive and Trafficking Properties of Donor Splenic and Bone Marrow Dendritic Cells.” Transplantation 2006;81:455-462.

      Cardona K, Korbutt GS, Zvonimir M, Lyon J, Cano J, Joang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangapa S, Weber J, Pearson TC, Rajotte R, Larsen CP. :Long term survival of neonatal porcine islets in honhuman primates by targeting costimulation pathways.” Nat. Med. 2006 Mar, 12 (3):304-6. Epub 2006 Feb 26.

      Larsen CP, Knechtle SJ, Adams A, Pearson TC, Kirk AD. “A New look at Blockade of T-cell Costimulation: A Therapeutic Strategy for Long-germ maintenance immunosuppression.” Am J Transplant. 2006 May;6(5):876-83.

      Kean LS, Gangappa S, Pearson TC, Larsen CP. “Transplant tolerance in non-human primates: progress, current challenges and unmet needs.” Am J Transplant 2006 May;6(5):884-93

      Han Lee ED, Kemball CC, Wang J, Dong Y, Stapler DC Jr., Hamby KM, Gangappa S, Newell KA, Pearson TC, Lukacher AE, Larsen CP. “A mouse model for polyomavirus-associated nephropathy of kidney transplants. Am J. Transplant. 2006 May’6(5);913-22.

      Marks WH, Wagner D, Pearson TC, Orlowski JP, Nelson PW, McGowan JJ, Guidinger MK, Burdick J. “Organ donation and utilization, 1995-2004: entering the collaborative era.” Am J Transplant. 2006; 6 (5 Pt 2): 1101-10.

      Bray RA, Nolen JDL, Larsen C, Pearson T, Newell KA, Kokko K, Guasch A, Tso P, Mendel J, Gebel HM. “Transplanting the highly sensitized patient: The Emory algorithm.” Am J Transplant. 2006 6:2307-2315.

      Vezys V, Masopust D, Kemball CC, Barber DL, O’mara LA, Larsen CP, Pearson TC, Ahmed R, Lukacher AE. “Continuous recruitment of naïve T cells contributes to heterogeneity of antiviral CD* T cells during persistent infection.” J Exp Med. 2006 Sep 11;[Epub ahead of print

      Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.” The Journal of Experimental Medicine. In press 2007.

      Gangappa,S, Larsen CP, Pearson TC. “Alloimmunity: No Toll Exemption.” American Journal of Transplantation. 2007: 7:3-4.

      Ford M, Koehn B, Wagener M, Jiang W, Gangappa S, Pearson TC, Larsen, CP. “Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. The Journal of Experimental Medicine. Vol. 204, No. 2, Feb. 2007:299-309.

      Ford M, Wagener M, Gangappa S, Pearson TC, Larsen CP. “Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models. Am J Tranplant. 2007 Jun;7(6):1471-81.

  • Kenneth Newell

    Taylor RT. Lugering A. Newell KA. Williams IR. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. [Journal Article] Journal of Immunology. 173(12):7183-9, 2004 Dec 15.