Emory Healthcare Now Enrolling Patients in Clinical Trial Targeting Osteoarthritis with Stem Cell Therapy

Emory Healthcare is conducting a research study to identify a superior source of stem cells for the treatment of osteoarthritis and to validate its advantages over corticosteroid injections.

The Multicenter Trial of Stem Cell Therapy for Osteoarthritis, or “MILES” study, is currently enrolling study subjects who have been diagnosed with knee osteoarthritis. People who are enrolled in the trial will go through a pre-screening process, including an initial exam and X-rays. Those who qualify must agree to participate in the study for one year.

Subjects will be required to attend seven (7) study visits, which may include procedures, injections and/or blood draws. They will have three (3) MRIs over the course of the year. In addition, subjects will be expected to complete a questionnaire after each visit to describe how they are feeling, document pain levels, and report any changes in functionality of the knee. Emory Healthcare is not promising subjects any specific result.

Who is eligible?

  • Anyone between the ages of 40 and 70 who have been diagnosed with knee osteoarthritis
  • Lives within a three hour driving distance from Atlanta
  • Must have an average daily pain score that is at least 3 out of 10 in severity
  • Have a recent knee radiograph of the targeted knee with a Kellgren-Lawrence Grade of II, III, or IV
  • No viscosupplementation within the past six months in the targeted knee
  • No Biologic Injection (PRP or stem cell) within the past year in the targeted knee
  • No surgery in the targeted knee within the past six months (either open or scope)
  • No systemic or intra-articular injection of corticosteroids in any joint within the past three months

4 Types of Treatment

Study subjects will be randomly chosen to receive one of four treatments. All possibilities will be discussed in detail during the pre-screening process.

  • Bone Marrow Concentrate. Two ounces of bone marrow is extracted from the subject in order to create an aspirate containing the stem cells needed for injection.
  • Stromal Vascular Fraction (SVF) from Adipose Tissue. Approximately four ounces of abdominal fat is harvested from the subject and broken down with enzymes to release the stem cells to be injected back into the patient.
  • Human Umbilical Cord Tissue. Donated umbilical cords are processed under best practices then injected at the site.
  • Corticosteroid Injections. The current gold standard in treating osteoarthritis

Physician & Study Location

Ken Mautner, MD
Emory Sports Medicine Complex
1968 Hawks Lane
Brookhaven, GA 30329

Charges & Compensation

The initial consultation (which includes X-rays) will be billed to the subject's insurance provider as a specialist office visit. Once enrolled, all study activities will be free of charge. Subjects will be compensated $50 for the two MRIs completed post-procedure. No other compensation will be provided.

Apply to Enroll Now

If you are interested in participating in the MILES study, please complete the form below and a research coordinator will contact you to provide more details. For any questions, contact Tiffany Dumas, Clinical Research Coordinator with Emory Sports Medicine Center, at 404-778-7881 or tdumas2@emory.edu or Alison Akard , clinical research manager at aakard@emory.edu.

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