Primary sclerosing cholangitis (PSC) is a disease that, over time, causes permanent damage to the liver's bile ducts. In people with PSC, inflammation and scarring cause the bile ducts to become blocked. Bile then accumulates in the liver, where it gradually causes cirrhosis (scarring). Backed-up bile can also become infected, causing acute illness. As scar tissue replaces healthy liver tissue, the liver loses its ability to function.
Most people want to know about primary sclerosing cholangitis life expectancy. All this described above happens very slowly, over the course of 10 to 15 years. Most people with PSC are asymptomatic, especially early on. When symptoms do develop, they tend to come and go.