Adeboye O. Osunkoya, MD

Research Interests: Urologic/Genitourinary Pathology My research interests are mainly in the field of Urologic/Genitourinary pathology. Prostate: We have studied the largest series to date of mucinous prostate cancer, colon cancer with prostatic involvement, primary mucin-producing urothelial-type adenocarcinoma of prostate and prostate cancer with aberrant p63 expression. We have also analyzed the expression of MUC-2, VEGF and ZEB-1 in prostate cancer, and have utilized multiplexed quantum dots in molecular mapping of tumor heterogeneity on tissue specimens of patients with prostate cancer. Kidney: We have analyzed diagnostic biomarkers for renal cell carcinoma (RCC), based on a selection utilizing novel bioinformatics systems for microarray data analysis. We have also studied the utility of Claudin 7 and 8 in the distinction between renal oncocytoma and chromophobe RCC, and the expression of PAX-2 and CA-IX in RCC. In addition, we are one of the first groups to confirm the distinction between tubulocystic carcinoma and collecting duct carcinoma of the kidney at the molecular level, based on comparison of gene expression profiles. Urinary Bladder: We are one of the first groups to describe a unique variant of bladder cancer (urothelial carcinoma with villoglandular differentiation). We have also analyzed one of the largest series to date of plasmacytoid urothelial carcinoma and smooth muscle neoplasms of the urinary bladder. Testis: We have analyzed the significance of rete testis involvement by malignant germ cell neoplasia and/or intratubular germ cell neoplasia. We have also studied lymphoid neoplasms of the urinary tract and male genital organs.

Clinical Focus: My clinical focus is in Surgical Pathology with major emphasis on Urologic/Genitourinary Pathology. I sign out general Surgical Pathology cases and frozen sections at both Emory University Hospital and the Veterans Affairs Medical Center. I also sign out autopsies, gynecologic and non-gynecologic cytology (including urine cytology) cases at the latter. I handle in house Urologic/Genitourinary Pathology consultation cases from Emory University Hospital, Veterans Affairs Medical Center, Emory Midtown Hospital, Grady Hospital and Children's Healthcare of Atlanta at Egleston and Scottish Rite. In addition, I offer expert consultation from outside institutions in the area of Urologic/Genitourinary Pathology (please see separate website link: http://pathology.emory.edu/ExpertConsultation_Forms.html) I have a secondary appointment in the department of Urology and I am active in their tumor boards at both the Emory University Hospital and the Veterans Affairs Medical Center.