Peripheral nervous system is comprised of the nerves that communicate between the brain and muscles, skin, internal organs and blood vessels. It also includes nerves in the face, arms, legs and torso. When damaged, nerves are unable to communicate properly, which can result in symptoms such as pain, numbness or weakness. Neuropathy symptoms vary depending upon the type of affected nerve. Some nerves affect the senses, others affect movement and motor skills, and some carry vital information to organs.
Peripheral neuropathies can be inherited (including Charcot-Marie-Tooth Disease) or acquired. Common acquired peripheral neuropathies are caused by an underlined medical conditions such as diabetes, vitamin deficiency (particularly B12), collagen vascular disorders (Lupus, Rheumatoid arthritis), toxins (heavy metals, led) and medications such as cancer therapy drugs. Some neuropathies are a result of inflammatory or immune process as seen in GBS or CIDP. Compressive peripheral neuropathies develop as a result of a peripheral nerve entrapment, as in the case of carpal tunnel syndrome.